Preparation of micro-nano structure bionics valve, surface congeal-resistance and drag reduction testing method thereof

A technology of bionic valves and micro-nano structures, which is applied in the field of medical implants, can solve problems such as film or coating shedding and affect performance, and achieve the effect of stable surface structure, preventing the formation of thrombus, and not being easily damaged

Inactive Publication Date: 2008-09-03
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Looking at these studies, it can be found that surface treatment of artificial heart valves can improve its blood compatibility, but the film or coating made by the above method is easy to fall off from the surface of the valve, thus affecting its performance

Method used

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  • Preparation of micro-nano structure bionics valve, surface congeal-resistance and drag reduction testing method thereof
  • Preparation of micro-nano structure bionics valve, surface congeal-resistance and drag reduction testing method thereof
  • Preparation of micro-nano structure bionics valve, surface congeal-resistance and drag reduction testing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Artificial heart valve with grating structure

[0025] 1. Design of microstructure of valve surface

[0026] Grating structure parameters such as figure 1 As shown in (a), a and b are the ridge width and groove width of the grating, respectively, and h is the ridge depth. According to the formula of Wenzel theory and Cassie theory in classical wetting theory cos θ r w = r cos θ e , cos θ r C = - 1 + f ( cos θ e + 1 ) The relationship between the geometric parameters of the valve surface and the apparent contact angle of the grating fine structure can be determined as

[0027] ...

Embodiment 2

[0046] Example 2: Prosthetic heart valve with square microcolumn structure

[0047] 1. Design of microstructure of valve surface

[0048] The structural parameters of periodic regular arrangement of square micropillars are as follows: figure 1 As shown in (b), a is the side length of the square column, b is the distance between the square columns, and h is the height of the square column (that is, the depth of the groove). According to the Wenzel formula cos θ r w = r cos θ e and the Cassie formula, cos θ r C = - 1 + f ( cos θ e + 1 ) The relationship between the geometric parameters and the apparent contact angle ...

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Abstract

The invention relates to a medical graft, which is applied to various artificial prosthesis cardiac valves. A fine structure form on the surface of an artificial cardiac valve is designed through determining the structural geometric parameters that are a, b, and h according to a biological prototype of the cardiac valve, the apparent contact angle calculation formula of the surface which is denoted by the geometric parameters is deduced, the proper fine structural geometric parameters are determined according to the calculation formula to lead the apparent contact angle on the cardiac valve surface to be larger than 150 degrees, so as to gain a more ideal super-hydrophobic surface; then a template which is provided with a fine structure surface is processed by utilizing the technology of femtosecond laser machining, and is washed, dried and processed through the silanization treatment; a PDMS valve surface which has the same fine structure with the template is copied by using a soft lithography method. The valve surface structure made by the invention is stable, has obvious characteristics of anticoagulation resistance and drag-reduction, effectively prevents the thrombosis, is hard to be damaged when being used for a long time, and is reusable without damage and deformation. Therefore, the mass production can be completed. In addition, the test method is simple and reliable.

Description

technical field [0001] The invention relates to medical implants, in particular to a method for manufacturing a bionic valve with a micro-nano structure and a method for testing its surface anticoagulation and drag reduction performance, which can be applied to various artificial prosthetic heart valves. Background technique [0002] The organic diseases of human heart valves due to various etiologies can be treated by replacing artificial valves through cardiac surgery. Since Albert Starr, a Polish cardiologist in the United States, successfully performed the first heart valve replacement in the early 1960s, the development of artificial heart valves has become more and more mature, and they are being used more and more in heart surgery. [0003] At present, artificial heart valves commonly used at home and abroad are divided into biological valves and mechanical valves according to materials. The biological valve made of biological tissue material simulates the shape and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/24G01N27/04
Inventor 周明叶霞李健蔡兰
Owner JIANGSU UNIV
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