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Pullulan polysaccharide Vc coating combination

The technology of pullulan polysaccharide and composition is applied in the directions of drug combination, medical preparation of inactive ingredients, metabolic diseases, etc. It can solve the problems of penetration safety, easy oxidation of Vc coating, and achieve high antioxidant, The effect of preventing sticking and avoiding residues of organic solvents

Inactive Publication Date: 2011-04-06
吕兴文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects that the existing Vc coating made of cellulose ether is easy to oxidize, still have relatively large penetration and poor safety to oxygen and moisture, and provide a kind of anti-oxidation, high bulk density and mechanical strength, anti-oxidation Sticky Vc coating composition

Method used

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  • Pullulan polysaccharide Vc coating combination

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Experimental program
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Effect test

Embodiment

[0015] Take the following cellulose ethers:

[0016] 1. Hydroxypropylmethylcellulose (HPMC), the technical indicators are: DS=1.88, MS=0.19, and the viscosity is 50mPa·S.

[0017] 2. Methyl cellulose (MC), the technical index is: DS=1.73, the viscosity is 15mPa·S.

[0018] 3. Hydroxyethyl cellulose (HEC), the technical index is: MS=1.80, the viscosity is 100mPa·S.

[0019] The alkyl or hydroxyalkyl substitution degree of the above-mentioned cellulose ether is at least 1.4 alkyl or hydroxyl in each glucose chain link.

[0020] Take pullulan polysaccharide (pull), the technical index is: the molecular weight is 20,000-100,000 Daltons, or the viscosity of a 10% aqueous solution by weight is 2-500 mPa·S at 20°C.

[0021] The above-mentioned pullulan and cellulose ether are formulated into different compositions in different weight ratios as shown in the table below, dissolved in pure water to make an aqueous solution with a concentration of 15-30% for use, and then Vc is tested ...

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Abstract

The invention discloses a combination of Pulullan polysaccharide Vc coating, which comprises 10 to 90 parts by weight of Pullullan polysaccharide and 90 to 10 parts by weight of cellulose ether. Ether substituents of the cellulose ether are chosen from alkyl or hydroxyalkyl. The invention also discloses a Vc coating method by using the Pullullan polysaccharide Vc combination, which is applicable to all existing Vc coating techniques, but a solvent for the method is pure water rather than ethanol; concentration of solution is controlled at 15 to 30 percent. The combination of the Pullullan polysaccharide and the cellulose ether used for Vc coating in the invention not only can prepare the aqueous solution with high concentration, but prevent 'adhesion'. The coating product of the inventionhas higher anti-oxidation ability and higher accumulation density and mechanical strength than that of using the cellulose ether alone.

Description

technical field [0001] The invention belongs to the field of fine chemicals, in particular to a pullulan Vc coating composition and the application of the composition to Vc C Method of coating. Background technique [0002] V C The molecule has a dienol structure, which is easily oxidized by air, especially affected by moisture, light, temperature, metal ions, etc., making V C The content decreased, the color turned yellow, etc. In the process, changing V C There are many methods for stability, such as direct compression method, changing formula composition, controlling granulation process conditions, etc. In recent years, V C Manufacturers in order to increase the V C Stability, especially oxidation resistance, mostly for V C Granule coating made of 97%, 98% V C Coated granules, commonly known as 97, 98 granules, and the remaining 2% to 3% are cellulose ethers. Cellulose ether can be dissolved in alcohol aqueous solution, which can reduce water residue during coat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K31/375A61K47/38A61P3/02
Inventor 吕兴文
Owner 吕兴文