Compound ambroxol sustained-release drop pills and preparation method thereof

Abstract

The invention discloses a drug combination oral pill preparation which takes Ambroxol hydrochloride and Clenbuterol hydrochloride as drug active ingredients and is used for relieving cough, dissolving phlegm and relieving asthma. The invention aims at overcoming the defects of the present therapeutic drug preparation for relieving cough, dissolving phlegm and relieving asthma and providing the drug combination preparation, namely, a compound Ambroxol sustained-release pill preparation which is characterized by high bioavailability, rapid effect, less times of medicine taking for patients, long acting time, less toxic and side effect and convenient application and carrying for patients and medical workers. The compound Ambroxol sustained-release pill related by the invention uses Ambroxol hydrochloride and Clenbuterol hydrochloride as drug active ingredients and is prepared by mixing the active ingredients with a hydrophilic framework material and a hydrophobic framework material that are used as substrate.

Description

technical field [0001] The present invention relates to a kind of therapeutic drug for relieving cough, reducing phlegm and relieving asthma, in particular to a pharmaceutically acceptable carrier, ambroxol hydrochloride and clenbuterol hydrochloride, which are mixed with hydrophilic skeleton material and hydrophobic skeleton material as matrix An oral preparation prepared together with the active ingredients of a drug. Background technique [0002] Ambroxol is the metabolite of bromhexine in the body. It has the effect of dissolving mucus and breaking the mucous fibers in the sputum to dilute the sputum. It also reduces the viscosity of sputum by inhibiting the synthesis of glycoproteins, making it easier to discharge the sputum. It is suitable for viscous sputum and difficulty in expectoration caused by acute and chronic respiratory diseases (such as acute and chronic bronchitis, bronchial asthma, bronchiectasis, tuberculosis, etc.). [0003] Chronic obstructive pulmonary...

AI Technical Summary

Problems solved by technology

[0008] Due to the preparation technology and other reasons, the oral preparations of most drugs have long dissolution time, low dissolution rate, poor absorption, frequent doses, unstable blood drug concentration, hepatic first-pass effect and low bioavailability after taking the oral preparations. And other problems, which affect the efficacy of the drug, but also directly affect the therapeutic effect