Compound ambroxol sustained-release drop pills and preparation method thereof

A technology of compound ambroxol and sustained-release dropping pills, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Unsteady, affecting the treatment effect and other problems, to achieve the effect of being conducive to labor protection and environmental protection, improving bioavailability, and being easy to carry around

Inactive Publication Date: 2008-10-22
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0008] Due to the preparation technology and other reasons, the oral preparations of most drugs have long dissolution time, low dissolution rate, poor absorption, frequent doses, unstable blood drug conc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] Now with regard to the compound ambroxol sustained-release dripping pill of the present invention, further describe with several groups of preferred specific examples.

[0044] First group:

[0045] Based on a total weight of 100g, weigh 20% of the matrix PEG6000, 40% of PEG4000, 14% of stearic acid, 6% of stearyl alcohol, 20% of the raw material ambroxol hydrochloride, and 0.007% of the raw material clenbuterol hydrochloride; Heat and stir in the heating container to melt, add the corresponding proportion of ambroxol hydrochloride and clenbuterol hydrochloride, stir well, and under the condition of heat preservation, drop the molten or mixed liquid medicine into the simethicone In the condensate column, the temperature when heating and melting is 55°C, the temperature of the upper part of the condensate is 30°C, and the temperature of the bottom is -2°C; take it out after forming.

[0046] The obtained product has a 2-hour cumulative release percentage of 32-53%, a 6-...

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PUM

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Abstract

The invention discloses a drug combination oral pill preparation which takes Ambroxol hydrochloride and Clenbuterol hydrochloride as drug active ingredients and is used for relieving cough, dissolving phlegm and relieving asthma. The invention aims at overcoming the defects of the present therapeutic drug preparation for relieving cough, dissolving phlegm and relieving asthma and providing the drug combination preparation, namely, a compound Ambroxol sustained-release pill preparation which is characterized by high bioavailability, rapid effect, less times of medicine taking for patients, long acting time, less toxic and side effect and convenient application and carrying for patients and medical workers. The compound Ambroxol sustained-release pill related by the invention uses Ambroxol hydrochloride and Clenbuterol hydrochloride as drug active ingredients and is prepared by mixing the active ingredients with a hydrophilic framework material and a hydrophobic framework material that are used as substrate.

Description

technical field [0001] The present invention relates to a kind of therapeutic drug for relieving cough, reducing phlegm and relieving asthma, in particular to a pharmaceutically acceptable carrier, ambroxol hydrochloride and clenbuterol hydrochloride, which are mixed with hydrophilic skeleton material and hydrophobic skeleton material as matrix An oral preparation prepared together with the active ingredients of a drug. Background technique [0002] Ambroxol is the metabolite of bromhexine in the body. It has the effect of dissolving mucus and breaking the mucous fibers in the sputum to dilute the sputum. It also reduces the viscosity of sputum by inhibiting the synthesis of glycoproteins, making it easier to discharge the sputum. It is suitable for viscous sputum and difficulty in expectoration caused by acute and chronic respiratory diseases (such as acute and chronic bronchitis, bronchial asthma, bronchiectasis, tuberculosis, etc.). [0003] Chronic obstructive pulmonary...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/137A61K47/34A61P11/10A61K47/10
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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