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Chinese medicinal composition, preparation method and application thereof

The technology of a composition and a traditional Chinese medicine is applied in the application field of preparing medicines for treating colds, which can solve the problems of easy loss of volatile oil components, difficulty in guaranteeing the efficacy of medicines and the like, and achieve the effects of good inclusion effect, easy industrial application and simple operation.

Active Publication Date: 2008-10-29
山东罗欣乐康制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The volatile oil contained in the three herbs of forsythia, notopterygium and peppermint has good antibacterial and antiviral effects, but the volatile oil components are easily lost during the extraction and preparation process, and it is difficult to guarantee the curative effect of the drug

Method used

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  • Chinese medicinal composition, preparation method and application thereof
  • Chinese medicinal composition, preparation method and application thereof
  • Chinese medicinal composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0162] a. Weigh 400g of raw medicinal materials Forsythia, 200g of Qianghuo, and 200g of mint, mix them, and crush them into 20-mesh granules;

[0163] b. Supercritical extraction of Forsythia, Qianghuo and Peppermint: at an extraction pressure of 25MPa, an extraction temperature of 60℃, and CO 2 Extract for 1.5 hours at a flow rate of 30L / h, and separate and collect the volatile oil;

[0164] c. Inclusion of volatile oil: Take the volatile oil and β-cyclodextrin at a ratio of 1:10 by weight of volatile oil and β-cyclodextrin, and add β-cyclodextrin to β-cyclodextrin with a weight of β-cyclodextrin weight 2 The doubled amount of water is evenly ground to prepare a β-cyclodextrin aqueous solution. The volatile oil is added with ethanol with a volume of 20% of the volatile oil to prepare a volatile oleyl alcohol solution. The clathrate is carried out by grinding method, the clathrate time is controlled to be 40 minutes, and the clathrate is obtained by suction filtration, washing, a...

Embodiment 2

[0166] a. Weigh 300g of Forsythia suspensa, 100g of Qianghuo, and 100g of mint, and mix them, crush them into 60-mesh granules;

[0167] b. Supercritical extraction of Forsythia, Qianghuo and Peppermint: at extraction pressure 35MPa, extraction temperature 60℃, CO 2 Extract for 2 hours at a flow rate of 40L / h, separate and collect the volatile oil;

[0168] c. Inclusion of volatile oil: Take the volatile oil and β-cyclodextrin at a ratio of 1:8 by weight of volatile oil and β-cyclodextrin, and add β-cyclodextrin to β-cyclodextrin with a weight of 4 The doubled amount of water is evenly ground to prepare a β-cyclodextrin aqueous solution. The volatile oil is added with ethanol with a volume of 30% of the volatile oil to prepare a volatile oleyl alcohol solution. The clathrate is carried out by grinding method, the clathrate time is controlled to be 40 minutes, and the clathrate is obtained by suction filtration, washing, and vacuum drying at 40°C.

Embodiment 3

[0170] a. Weigh 500g of Forsythia suspensa, 300g of Qianghuo, and 300g of peppermint, and mix them, and crush them into 40-mesh granules;

[0171] b. Supercritical extraction of Forsythia, Qianghuo and Peppermint: at extraction pressure 30MPa, extraction temperature 45℃, CO 2 Extract for 3 hours at a flow rate of 20L / h, and separate and collect the volatile oil;

[0172] c. Inclusion of volatile oil: Take the volatile oil and β-cyclodextrin at a ratio of 1:12 by weight of volatile oil and β-cyclodextrin, and add β-cyclodextrin to β-cyclodextrin with a weight of 3 The doubled amount of water is evenly ground to prepare a β-cyclodextrin aqueous solution. The volatile oil is added with ethanol with a volume of 10% of the volatile oil to prepare a volatile oleyl alcohol solution. The clathrate is carried out by grinding method, and the clathrate time is controlled to 60 minutes. The clathrate is obtained by suction filtration, washing, and vacuum drying at 40°C.

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Abstract

The invention discloses a traditional Chinese medicine composition, a preparation method and application thereof. The traditional Chinese medicine composition firstly smashes weeping forsythiae capsule, incised notopterygium rhizome and peppermint and then adopts CO2 supercritical extraction or steam distillation for extraction, thus obtaining volatile oil; the volatile oil and Beta-cyclodextrin are taken according to the weight ratio of 1: 8 to 12, water with the weight which is 2 to 4 times of that of the Beta-cyclodextrin is added in the Beta-cyclodextrin for even grinding, thus preparing Beta-cyclodextrin water solution; ethanol with the volume which is 10 to 40 percent of that of volatile oil is added in the volatile oil, thus preparing volatile oil alcohol solution; the inclusion is carried out by grinding, the inclusion time is 20 to 60 minutes, and the traditional Chinese medicine composition is prepared by filtering and washing an inclusion compound and drying at 40 DEG C. The traditional Chinese medicine composition of the invention is used for the preparation of drugs for treating cold, the efficacy is significant, and the preparation process of the inclusion compound has low cost, simple operation, good inclusion effect and easy industrial application.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a traditional Chinese medicine composition. The invention also relates to a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparing medicines for treating colds. Background technique [0002] Forsythia is the dried fruit of Forsythia suspense (Thunb.) Vahl. Mainly containing phenethyl alcohol glycosides such as: forsythin, forsythia phenol and other compounds, volatile oil 1 to 2.5%, etc., are broad-spectrum antibacterial drugs, have inhibitory effects on a variety of Gram-positive and negative bacteria, and its volatile oil has the effect of gold Staphylococcus aureus, pneumococcus and Candida albicans have obvious inhibitory effect, and its decoction has antipyretic effect [1] . Qianghuo is the dry rhizome and root of Notopterygium incisum Ting ex H.T.Chang or Notoperygium forbe...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K47/48A61P11/00A61K47/69
Inventor 李运曼方伟蓉龚晓健濮存海
Owner 山东罗欣乐康制药有限公司