Medicament composition for treating otitis medium and preparation thereof

A composition and otitis media technology, applied in the direction of drug combination, pharmaceutical formula, hydroxyl compound active ingredients, etc., can solve the problems of chemical antibiotic ear drops not obvious effect, direct toxicity of inner ear, affecting hearing, etc., so as to achieve drug resistance sex, no obvious side effects, short course of treatment

Active Publication Date: 2011-11-23
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the wide application of various antibiotics and the increase of drug-resistant strains, the effect of chemical antibiotic ear drops is not obvious. Some aminoglycoside antibiotics have direct toxic effects on the inner ear, damage the cochlea, and affect hearing, resulting in drug-induced deafness in some patients. Most external medicines are powder, ointment, and oil preparations, which are easy to produce earwax after use and are difficult to remove, affecting hearing, thus limiting clinical use

Method used

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  • Medicament composition for treating otitis medium and preparation thereof
  • Medicament composition for treating otitis medium and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Example 1: Preparation of ear drops

[0082] Coptis 200g, borneol 50g, dry alum 150g, alum 30g, keel 15g, sea cuttlefish 15g

[0083] Take coptis, borneol, dry alum, alum, keel, and cuttlebone respectively and crush them, mix the coptis, keel and cuttlebone, add 1000ml of 60% ethanol and soak for 10 days, stir once a day, every 30 minutes, Pour out the supernatant, filter, squeeze the residue, combine the squeezed liquid with the filtrate and the supernatant; let stand for 24 hours, filter, add alum, cumulon, and borneol to the filtrate, add 20ml of benzyl alcohol after dissolution, and then add 60% ethanol to 1000ml, mix well, and get ready.

Embodiment 2

[0084] Example 2: Preparation of ear drops

[0085] Coptis 100g, borneol 50g, dry alum 300g, alum 50g, keel 5g, sea cuttlefish 30g

[0086] Take coptis, borneol, dry alum, alum, keel, and cuttlebone respectively and crush them, mix the coptis, keel and cuttlebone, add 500ml of 40% ethanol and soak for 2 days, stir 3 times a day, each time for 60 minutes, Pour out the supernatant, filter, squeeze the residue, combine the squeezed liquid with the filtrate and the supernatant; let stand for 6 hours, filter, add alum, cumulon, and borneol to the filtrate, add 50ml of benzyl alcohol after dissolution, and then add 40% ethanol to 1000ml, mix well and get ready.

Embodiment 3

[0087] Example 3: Preparation of ear drops

[0088] Coptis 300g, borneol 100g, dry alum 100g, alum 20g, keel 15g, sea cuttlefish 30g

[0089] Take coptis, borneol, dry alum, alum, keel, and cuttlebone respectively and crush them, mix the coptis, keel and cuttlebone, add 2000ml of 80% ethanol and soak for 20 days, stir twice a day, 20 minutes each time, Pour out the supernatant, filter, squeeze the residue, combine the squeezed liquid with the filtrate and the supernatant; let stand for 72 hours, filter, add alum, alum, and borneol to the filtrate, add 10ml of benzyl alcohol after dissolving, and then add 80% ethanol to 1000ml, mix well and get ready.

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Abstract

The invention discloses a traditional Chinese medicine compound medicine composition for treating otitis media and a preparation process thereof. The traditional Chinese medicine compound medicine composition for treating otitis media is mainly composed of golden thread, borneol, calcined alum, alum, fossilized and cuttlebone. The ear drops are characterized by rapid dry ear, high efficacy, shortcourse of treatment, no significant side effects, safe medication and so on.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating otitis media and its preparation process, in particular to a pharmaceutical composition for treating acute, chronic and suppurative otitis media and its preparation process. Background technique [0002] Acute, chronic, and suppurative otitis media are common and frequently-occurring diseases in otology clinics. People's Liberation Army navy, aviation, coastal fishermen and swimming enthusiasts are very susceptible to ear canal diseases, especially children. According to a survey of 1000 children aged 2-14 years by the British Graphics Research, among them, purulent otitis media accounted for 8% of newly diagnosed patients in otolaryngology, and domestic statistics accounted for 11.7% of newly diagnosed patients in otolaryngology. The susceptible bacteria are diverse. Due to the wide application of various antibiotics and the increase of drug-resistant strains, chemical antibiotic ear drops ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K9/10A61P27/16A61K31/045A61K35/56A61K35/02A61K33/06A61K35/618
Inventor 王利春梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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