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Compound alendronate sodium vitamine D3 orally disintegrating tablets and preparation method thereof

A technology of oral disintegrating tablet and alendronate sodium, which is applied in the field of compound alendronate sodium vitamin D3 oral disintegrating tablet and its preparation, and can solve the problem that no related documents and patents of prulifloxacin oral disintegrating tablet have been seen. reports, etc.

Inactive Publication Date: 2008-11-19
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Through the search, there are no relevant literature and patent reports on prulifloxacin orally disintegrating tablets

Method used

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  • Compound alendronate sodium vitamine D3 orally disintegrating tablets and preparation method thereof
  • Compound alendronate sodium vitamine D3 orally disintegrating tablets and preparation method thereof
  • Compound alendronate sodium vitamine D3 orally disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] prescription:

[0022]

[0023]

[0024] Preparation:

[0025] Add alendronate sodium vitamin D3 into Eudragit L30D suspension, add appropriate amount of water, stir evenly, add crospovidone, mannitol, orange essence, stir while adding, after forming a suspension, pour in In a suitable mold, freeze-dried, pressed and sealed, and packaged.

Embodiment 2

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Mix alendronate sodium vitamin D3, pregelatinized starch, mannitol, and lactose that have passed through an 80-mesh sieve evenly according to the method of equal addition, and mix protein sugar and pineapple essence with the above mixture, add micronized silica gel and mix evenly , the powder can be directly compressed into tablets.

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PUM

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Abstract

The invention relates to compound alendronate sodium vitamin D3 orally-disintegrating tablets used for preventing and treating stmenopausal osteoporosis and a preparation method thereof, aims to provide a novel preparation, i.e. the compound alendronate sodium vitamin D3 orally-disintegrating tablets to patients and medical workers; wherein, the compound alendronate sodium vitamin D3 orally-disintegrating tablets have fast absorption and high bioavailability, need no water when in administration, have little intestinal residue and insignificant side effects, and avoid the first-pass effect in liver sausage. Alendronate sodium vitamin D3 is used as a raw material, auxiliary materials are added in, and the alendronate sodium vitamin D3 orally-disintegrating tablets are prepared according to the technical means.

Description

technical field [0001] The invention relates to a medicine convenient to take and a preparation method thereof, in particular to a preparation method and application of alendronate sodium vitamin D3 orally disintegrating tablets for preventing and treating postmenopausal osteoporosis. Background technique [0002] The effect of alendronate sodium on bone weight gain is similar to that of estrogen, better than calcitonin, can significantly increase bone density, reduce the incidence of fractures, and is effective orally, with long-lasting effects, good tolerance and high safety sex. The drug does not have the risk of increased thrombosis and increased incidence of breast cancer when estrogen is used, and does not have the side effects of bone mineralization inhibition and osteomalacia caused by continuous administration of the first-generation drug etidronate. It is currently the most highly evaluated osteoporosis prevention and treatment drug in the international clinical c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61K31/663A61K47/38A61K47/36A61P19/10A61P15/12A61K31/593
Inventor 王蒙
Owner 北京利乐生制药科技有限公司
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