Alcohol-containing chlorhexidine iodine disinfectant and preparation method thereof
The technology of a disinfectant and chlorhexidine, which is applied in the field of rapid skin disinfectant and its preparation, can solve the problems of limited use, general sterilization effect, slow sterilization speed, etc., and achieves rapid penetration, good dispersibility, and sterilization. powerful effect
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[0039] Preparation method of disinfectant of the present invention
[0040] According to the composition and content of the above disinfectant, heat and mix chlorhexidine, iodine, and alcohol at 40-60℃ for 1-3 hours, then add stabilizer, penetrant, skin care agent, 10% phosphoric acid solution, and finally add water to 100%, the disinfectant is obtained.
[0041] The skin disinfectant of the present invention is tested for its killing effect on microorganisms according to the relevant provisions of the 2002 version of the "Disinfection Technical Specification". The average logarithmic value of killing E. coli in 0.5 min is> 5.00, and the average killing effect of 0.5 min on Staphylococcus aureus is Value> 5.00, 0.5min average killing logarithm of Candida albicans> 4.00, 0.5min average killing Pseudomonas aeruginosa> 5.00. The stability and safety of its products have been fully verified.
Embodiment 1
[0043] Add 10 grams of chlorhexidine acetate and 2 grams of iodine to 600 grams of 95% ethanol. Heat and mix for 2 hours at 40°C. Then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, 10 grams of glycerol, and 10% phosphoric acid. Mix 2 grams of solution and 367 grams of water to obtain the disinfectant.
[0044] After testing, the disinfectant in this example has an average logarithmic killing value of Escherichia coli in 0.5min> 5.00, 0.5min average killing of Staphylococcus aureus> 5.00, 0.5min average killing of Candida albicans Value>4.00, the average logarithmic value of killing Pseudomonas aeruginosa in 0.5min>5.00.
Embodiment 2
[0046] Add 6 grams of chlorhexidine acetate and 5 grams of iodine to 500 grams of isopropanol, heat and mix for 1 hour at 60°C, then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, 10 grams of glycerol, and 10% phosphoric acid. Disinfectant is obtained by mixing 5 grams of solution and 465 grams of water.
[0047] After testing, the disinfectant of this example has an average logarithmic killing value of E. coli in 0.5 min> 5.00, an average killing log value of Staphylococcus aureus at 0.5 min> 5.00, and an average killing of Candida albicans at 0.5 min The logarithm value>4.00, the average logarithm value of killing Pseudomonas aeruginosa in 0.5min>5.00.
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