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Alcohol-containing chlorhexidine iodine disinfectant and preparation method thereof

The technology of a disinfectant and chlorhexidine, which is applied in the field of rapid skin disinfectant and its preparation, can solve the problems of limited use, general sterilization effect, slow sterilization speed, etc., and achieves rapid penetration, good dispersibility, and sterilization. powerful effect

Inactive Publication Date: 2008-11-26
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of product has a slow sterilization speed and is not easy to dry, so it has limitations when it comes out;
[0005] Chlorhexidine-iodine complex aqueous solution type disinfectant, existing products both at home and abroad appear, Chinese patent (or open) CN1404811A, CN1126523C, CN1273032A and CN1105385A all have reports, but its foam is many, slippery, poor stability, bactericidal effect is general

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] Preparation method of disinfectant of the present invention

[0040] According to the composition and content of the above disinfectant, heat and mix chlorhexidine, iodine, and alcohol at 40-60℃ for 1-3 hours, then add stabilizer, penetrant, skin care agent, 10% phosphoric acid solution, and finally add water to 100%, the disinfectant is obtained.

[0041] The skin disinfectant of the present invention is tested for its killing effect on microorganisms according to the relevant provisions of the 2002 version of the "Disinfection Technical Specification". The average logarithmic value of killing E. coli in 0.5 min is> 5.00, and the average killing effect of 0.5 min on Staphylococcus aureus is Value> 5.00, 0.5min average killing logarithm of Candida albicans> 4.00, 0.5min average killing Pseudomonas aeruginosa> 5.00. The stability and safety of its products have been fully verified.

Embodiment 1

[0043] Add 10 grams of chlorhexidine acetate and 2 grams of iodine to 600 grams of 95% ethanol. Heat and mix for 2 hours at 40°C. Then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, 10 grams of glycerol, and 10% phosphoric acid. Mix 2 grams of solution and 367 grams of water to obtain the disinfectant.

[0044] After testing, the disinfectant in this example has an average logarithmic killing value of Escherichia coli in 0.5min> 5.00, 0.5min average killing of Staphylococcus aureus> 5.00, 0.5min average killing of Candida albicans Value>4.00, the average logarithmic value of killing Pseudomonas aeruginosa in 0.5min>5.00.

Embodiment 2

[0046] Add 6 grams of chlorhexidine acetate and 5 grams of iodine to 500 grams of isopropanol, heat and mix for 1 hour at 60°C, then add 5 grams of polyvinylpyrrolidone, 4 grams of azone, 10 grams of glycerol, and 10% phosphoric acid. Disinfectant is obtained by mixing 5 grams of solution and 465 grams of water.

[0047] After testing, the disinfectant of this example has an average logarithmic killing value of E. coli in 0.5 min> 5.00, an average killing log value of Staphylococcus aureus at 0.5 min> 5.00, and an average killing of Candida albicans at 0.5 min The logarithm value>4.00, the average logarithm value of killing Pseudomonas aeruginosa in 0.5min>5.00.

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PUM

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Abstract

The invention relates to a disinfectant, in particular to the rapid skin disinfectant and a preparation method thereof. The alcohol-containing chlorhexidine iodine disinfectant comprises components with the following percentages by weight: 0.1 to 4 percent of chlorhexidine; 0.1 to 5 percent of iodine; 30 to 80 percent of alcohol; 0.1 to 2 percent of stabilizer; 0.1 to 1 percent of penetrating agent; 0.1 to 2 percent of skin car agent; 0.1 to 0.8 percent of phosphoric acid solution with the concentration of 10 percent and the rest of water. The preparation method of any disinfectant is that: the chlorhexidine, the iodine and the alcohol are heated and mixed for 1 to 3 hours at the temperature of 40 to 60 DEG C according to the components and the contents, the stabilizer, the penetrating agent, the skin protective agent and the phosphoric acid of 10 percent are then respectively added, the water is added to 100 percent to be evenly mixed, and the disinfectant is obtained. The disinfectant of the invention can not only have high-efficient broad-spectrum and rapid special effects of sterilization, but can also have good safety and simple and rapid usage.

Description

Technical field [0001] The invention relates to a disinfectant, in particular to a rapid skin disinfectant and a preparation method thereof. Background technique [0002] At present, the commonly used skin disinfectants at home and abroad are: [0003] Chlorhexidine alcohol-based disinfectant, this disinfectant has been widely used in the international medical community for surgical hand disinfection and surgical site disinfection, etc. The clinical effect has proven its strong sterilization performance. It is a disinfecting ingredient commonly used in skin disinfectants in countries around the world. It is widely used internationally. The skin disinfectants produced by many multinational companies are still 0.5% chlorhexidine alcohol-based preparations, but the sterilization speed of such products is still It cannot be used for rapid disinfection of rescue patients and cannot indicate the disinfection area; [0004] Povidone-iodine aqueous solution type disinfectant is also wide...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61P17/00A61P31/02A61K31/155
Inventor 孙文胜王叔周卞雪莲张丽
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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