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Degradable stephanoporate stent material for inducting osseous tissue regeneration and repair and preparation thereof

A technology for bone tissue regeneration and porous scaffolds, applied in medical science, prostheses, etc., can solve the problems of fast degradation, high brittleness, unfavorable cell adhesion and proliferation, etc., and achieve simple preparation process, high porosity rate, and promotion of incorporation Effect of inducing bone tissue repair

Inactive Publication Date: 2013-06-12
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen has the problem of degrading too fast, so the cross-linking modification of collagen has improved the degradation performance of collagen, but there is still a problem of high brittleness.
Moreover, these scaffolds are formed by compaction, without forming a porous shape, which is not conducive to cell adhesion and proliferation

Method used

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  • Degradable stephanoporate stent material for inducting osseous tissue regeneration and repair and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 1% by weight of hydroxyapatite collagen composite powder was added to 0.01% by weight of ammonia solution and stirred uniformly, and 0.1% by weight of konjac glucomannan powder was added and stirred uniformly until a gel was formed. Put the jelly in a water bath at 40°C for 72 hours, then wash it with distilled water until it is neutral. Frozen at -10°C, and finally freeze-dried to prepare the required scaffold.

Embodiment 2

[0023] Example 2 1wt% of hydroxyapatite collagen composite powder was added to 0.1wt% of ammonia solution and stirred uniformly, 5wt% of konjac glucomannan powder was added and stirred uniformly until a jelly was formed. Put the jelly in a water bath at 40°C for 72 hours, then wash it with distilled water until it is neutral. Frozen at -10°C, and finally freeze-dried to prepare the required scaffold.

Embodiment 3

[0024] Example 3: Add 1% by weight of hydroxyapatite collagen composite powder into 1% by weight ammonia solution and stir evenly, and add 25% by weight of konjac glucomannan powder and stir evenly until a jelly is formed. Put the jelly in a water bath at 40°C for 72 hours, then wash it with distilled water until it is neutral. Frozen at -20°C, and finally freeze-dried to obtain the required scaffold.

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PUM

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Abstract

The invention discloses a degradable support material which induces the regeneration and repair of bone tissues and a preparation method thereof, pertaining to the technical field of the preparation of biomaterials. Degradable biomaterials, such as konjac glucan-mannan and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are adopted as raw materials in the invention. Konjac glucan-mannan powder and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are added into aqueous solution of an alkaline gelata and fully heated to form gel, and then after freeze-drying, the degradable porous support material is prepared. Not only does the materialhave simple preparation technology and low cost, but also the biomaterial prepared has good biocompatibility. Cell tests show that the material can be universally applied to bone operation and is theantibacterial porous material with adjustable degradation rate in vivo and can promote and induce the repair of the bone tissues, thereby having the wide application value in surgical operation.

Description

Technical field [0001] The invention relates to a bioengineering material and a preparation method thereof, in particular to a degradable material for bone tissue repair and regeneration, and belongs to the technical field of bioengineering materials. Background technique [0002] Nowadays, the development direction of bone scaffolds is to study bone scaffold materials with three-dimensional porous shape, a certain mechanical strength to support physiological pressure, degradation at a controllable rate, and good biocompatibility. [0003] Human natural bone is composed of hydroxyapatite (HAP) and collagen (Col). Therefore, a large number of studies have been conducted on collagen, hydroxyapatite and their combination in bone scaffolds at home and abroad. Prove that collagen, hydroxyapatite and the composite bone scaffold of the two have good biocompatibility and osteoconductivity, and are good bone repair materials. At present, research on bone scaffolds at home and abroad is ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/56
Inventor 陈庆华赵昆渝陈寰贝
Owner KUNMING UNIV OF SCI & TECH