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Tongbianling preparation and quality control method

A quality control method and laxative technology, which can be used in pill delivery, pharmaceutical formulations, measuring devices, etc., can solve problems such as long heating time, low extraction rate, thermal instability of active ingredients, etc.

Inactive Publication Date: 2009-01-07
刘建伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the thermal instability of sennosides, decoction, soaking in boiling water, ethanol reflux, etc. are used to extract, concentrate, and dry to obtain the active ingredients of senna leaves. The problem of loss of stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Granule (sugar-free type)

[0019] [Prescription] Senna 7200g Angelica 900g Cistanche 900g

[0020] [Preparation method] take senna leaf coarse powder (20 ~ 30 orders) according to the percolation method under the liquid extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix I O), make solvent ultrasonic with three times amount of 50% ethanol After 30 minutes of treatment, carry out percolation, collect 8 times the amount of percolation liquid of medicinal materials, concentrate under reduced pressure at low temperature to a clear paste with a relative density of 1.05-1.15 (60°C), spray dry (inlet air temperature 150-170°C, temperature 100-105°C) to make extract powder; 450g of angelica was crushed into fine powder, and the remaining angelica and Cistanche were decocted twice with 8 times of water, each time for 1.5 hours, filtered, and the filtrate was concentrated to a relative density of 1.20-1.26 (80°C) extract; take senna leaf extra...

Embodiment 2

[0021] Example 2 tablet

[0022] [Prescription] Senna 1200g Angelica 150g Cistanche 150g

[0023] [Preparation method] get senna leaf coarse powder (20 order powders), according to the percolation method (Chinese Pharmacopoeia 2005 edition an appendix 10) under the liquid extract and extract item, make solvent ultrasonic with 30% ethanol three times amount After 30 minutes of treatment, carry out percolation, collect 8 times the percolation liquid of the medicinal material, concentrate under low temperature and reduced pressure to a ointment with a relative density of 1.16-1.22 (60°C), spray dry (inlet air temperature 160-170°C, outlet air temperature 50~60℃) into extract powder. 75g of angelica is crushed into fine powder, and the remaining angelica and cistanche are decocted twice with 8 times the amount of water, each time for 1.5 hours, filtered, and the filtrate is concentrated into an extract with a relative density of 1.20-1.26 (80°C); take senna leaves Extract powder...

Embodiment 3

[0024] Embodiment 3 capsules

[0025] [Prescription] Senna 1200g Angelica 150g Cistanche 150g

[0026] [Preparation method] get senna leaf coarse powder (20 mesh powder), according to the percolation method (Chinese Pharmacopoeia 2005 edition an appendix I0) under the liquid extract and the extract item, add three times the amount of water as the solvent ultrasonic treatment 30 Carry out percolation after 10 minutes, collect the percolation liquid of 8 times the amount of medicinal material, concentrate under low temperature and reduced pressure to a ointment with a relative density of 1.16~1.22 (60°C), spray dry (inlet air temperature 160~170°C, air outlet temperature 50~ 60°C) into extract powder. 75g of angelica is crushed into fine powder, and the remaining angelica and cistanche are decocted twice with 8 times the amount of water, each time for 1.5 hours, filtered, and the filtrate is concentrated into an extract with a relative density of 1.20-1.26 (80°C); take senna le...

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Abstract

The invention relates to a Tongbianling Preparation and a quality control method thereof. The preparation is prepared from Folium Sennae (Cassia angustifolia and / or Cassia acutifolia) 1,200 g, Angelica sinensis 150 g and Cistanche deserticola 150 g by the steps of ultrasonic immersing, percolating, concentrating under reduced pressure, spray drying, spray granulating, and other low-temperature extracting and drying techniques. Compared with the original ministerial standards, the preparation maximally extracts and retains effective ingredients and has stable therapeutic effect. The quality control method comprising identification with thin layer chromatography and content determination ensures stable product quality.

Description

technical field [0001] The invention relates to a medicine preparation process and a quality control method, in particular to a Tongbianling preparation and a quality control method. Background technique [0002] Tongbianling Capsules are recorded in the seventh volume of the Ministry of Health’s Drug Standards for Traditional Chinese Medicine Prescriptions. The prescription is 1200g of Senna, 150g of Angelica, and 150g of Cistanche. The preparation method is to take 75g of Angelica and crush it into fine powder; Decoct leaves and other two flavors with water for 1.5 hours, filter, concentrate the filtrate into a thick paste, add angelica powder, mix well, dry at low temperature, pulverize, sieve, mix well, put into capsules to make 1000 capsules, and get ready. Senna leaves contain sennosides) A, B C, D, chrysophanol, emodin, emodin methyl ether. The water-soluble part of angelica contains ferulic acid, succinic acid, niacin, uracil, adenine, scopolamine, umbelliferone, va...

Claims

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Application Information

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IPC IPC(8): A61K36/64A61K9/20A61K9/16A61K9/48A61K9/46G01N30/02G01N30/90A61P1/10
Inventor 王根太刘建伟
Owner 刘建伟
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