Electrochemical method for preparing hydroxylapatite granule thin coating on metallo-implantation surface
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A technology of hydroxyapatite and implants, which is applied in coatings, prostheses, medical science, etc., can solve the problems of large hydroxyapatite particles, low metal binding force, and difficult control, and achieve uniform thickness, It is not easy to fall off and has the effect of improving the bonding strength
Inactive Publication Date: 2009-02-04
ZHEJIANG UNIV
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However, the coatings obtained in the electrolytes used in the existing published documents have the disadvantages of large hydroxyapatite particles, low binding force with the base metal, thick coatings and difficult control, etc., so no practical applications have been obtained. Clinical application
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Embodiment 1
[0027] Electrolyte composition:
[0028] Elements of Hap: Ca(NO 3 ) 2 ---0.3mM / L,
[0029] NH 4 h 2 PO 4 ---0.18mM / L,
[0030] pH=5;
[0031] Additive: Na 3 C 6 h 5 o 7 2H 2 O---0.3mM / L
[0032] Conductive agent: NaNO 3 ---0.01M / L
[0033] Electrolyte temperature: 30°C
[0034] Deposition time: 0.5 hours
[0035] Deposition voltage: 2V
[0036] A uniform thin coating of hydroxyapatite particles is obtained on the surface of metal titanium. The Hap particles are conical, and the diameter gradually decreases from the bottom to the top. The top diameter is about 50nm and the length is about 150nm. figure 1 And attached figure 2 shown.
Embodiment 2
[0038] Electrolyte composition:
[0039] Hap constituent elements: C 6 h 10 CaO 6 ---6mM / L,
[0040]NH 4 h 2 PO 4 ---3.6mM / L,
[0041] pH=12;
[0042] Additive: Na 3 C 6 h 5 o 7 2H 2 O---60mM / L
[0043] Conductive agent: C 3 h 5 NaO 3 ·5H 2 O---1M / L
[0044] Electrolyte temperature: 95°C
[0045] Deposition time: 5 hours
[0046] Deposition voltage: 4V
[0047] Above-mentioned electrolyte composition is made up of physiological ion completely, got rid of nitrate ion (NO in example 1 3 - ) may have adverse effects on biocompatibility. A uniform thin coating of hydroxyapatite particles is obtained on the surface of metal titanium. The Hap particles are irregular columns with a diameter of about 150nm and a rough surface. image 3 And attached Figure 4 shown.
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Abstract
The invention discloses an electrochemical method for preparing a hydroxylapatite particle thin coating on the surface of a metal implant, which comprises the following steps: electrolyte is put into a container equipped with a constant temperature heating system and heated to be 30 DEG C to 95 DEG C, and then the temperature is kept; platinum is taken as the anode and evenly distributed around the container, and the metal implant is taken as the cathode, put in the middle of the container and totally soaked in the electrolyte; DC voltage of 2V to 4V is added between the anode and the cathode, the surface of the metal implant has cathode reduction reaction, the pH value is increased and the supersaturation degree of the hydroxylapatite is also increased, so as to crystalize on the surface of titanium; after 0.5h to 5h of deposition, a layer of hydroxylapatite particle thin coating which can be excellently adhered to the matrix metal is formed on the surface of the implant. The hydroxylapatite particle thin coating prepared by the method is thin and even, is not easy to fall off during the operation process, can guide the bone tissue to quickly grow to the surface after being implanted into the bone tissue, so as to greatly improve the clinical success rate of the implant.
Description
technical field [0001] The present invention relates to a method for preparing a thin coating of hydroxyapatite particles, in particular to a method of rapid deposition on the surface of metal implants by electrochemical electrolysis in a calcium and phosphate solution containing citrate ion additives Method for thin coating of hydroxyapatite particles. Background technique [0002] Metal implants are widely used in orthopedics and dentistry, such as artificial joints and dental implants. The key to the success of metal implant implantation surgery is whether the implant can quickly grow to the implant surface and be firmly combined with the surface after it is implanted into bone tissue. The currently used titanium and titanium alloy implants need to heal and grow for a long time to form a firm combination with the surrounding bone tissue, which brings risks to the success of the implant. Therefore, a variety of surface treatment methods have been developed to address thi...
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