Preparation technique of high-purity scutellarin raw medicine

A technology of scutellarin and scutellarin, which is applied in the field of preparation of scutellarin raw materials, can solve problems that cannot be solved well, and achieve the effects of being beneficial to environmental protection, increasing content, and reducing production costs

Active Publication Date: 2009-03-04
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The refining method of scutellarin raw material medicine has not been solved well, so it is necessary to s

Method used

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  • Preparation technique of high-purity scutellarin raw medicine
  • Preparation technique of high-purity scutellarin raw medicine

Examples

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Embodiment 1

[0024] Weigh 1000g of commercially available scutellarin, wherein the content of scutellarin is 86%, put it in a stainless steel barrel, add boiling water to prepare a concentration of 20% by weight, stir well, and adjust the pH value to 7 with 20% sodium bicarbonate , to dissolve, the filtrate was first centrifuged by a 16000rpm continuous tube centrifuge, and then filtered, the filtrate was added to the D101 macroporous resin column, water was used as the eluent, and the eluate was collected until it was basically colorless. The eluent was concentrated to 1 / 20 of the original volume, 10 times the volume of acetone was added, stirred, allowed to stand for 10 hours, precipitated, filtered, and the mother liquor in the precipitate was washed with acetone to obtain scutellarin salt.

[0025] Move the obtained scutellarin salt into another container, add 8 times the volume of 50% acetone aqueous solution, stir well, adjust the pH to 1 with 10% hydrochloric acid, let it stand for 1...

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Abstract

The invention relates to a method for preparing scutellarin bulk drug with a purity above 99%. The method comprises the following steps: (1) adopting macroporous resin with a type of D101 or AB-8 macroporous resin, and water as a solvent, and filling a column; (2) preparing a breviscarpin on-column solution; (3) feeding the on-column solution in the step (2) into the macroporous resin column in the step (1), eluting with water as an eluent until the eluate substantially becomes colorless, and collecting the eluate; (4) concentrating the eluate under the reduced pressure at 60 to 70 DEG C into 1/10 to 1/20 of the original volume; (5) adding acetone or ethanol with the amount 10-15 times of the concentrate, stirring, standing, precipitating, filtering, and washing out the mother liquid in the precipitate with acetone to obtain a breviscarpin salt; and (6) adding 30% to 50% acetone aqueous solution with the amount 5-10 times of the volume of the breviscarpin salt, stirring, regulating the pH to 1-2 with organic acid, standing, filtering to obtain precipitate, and washing with water to neutrality to obtained the scutellarin bulk drug with high purity.

Description

technical field [0001] The invention relates to a preparation method of scutellarin B crude drug with a purity of more than 99%. Background technique [0002] Breviscapus is a flavonoid component isolated from the whole herb of Erigeron breviscapus (Vant) Hand-Mazz. According to the "Drug Standards" issued by the Ministry, the content of breviscapus in breviscapus injection should be more than 90%. . Because the current method of refining breviscapine raw material medicine is a refining method of imitating huangling glycosides, the product quality cannot meet the requirements of the standards issued by the Ministry. The refining method of scutellarin raw material medicine has not been solved well, so it is necessary to study a new refining method to make it meet the requirements of the "Drug Standards" issued by the Ministry. [0003] Chinese Patent Application No. 00113019.6 discloses a "effective part of Erigeron breviscapus and its preparation process and preparation", ...

Claims

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Application Information

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IPC IPC(8): C07H17/07
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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