Traditional Chinese medicine composition with antibiotic and anti-inflammation action and preparation method and quality control method thereof

An antibacterial, anti-inflammatory and composition technology is applied in the fields of traditional Chinese medicine compositions and their preparation methods and quality control, and can solve the problems of long heating time of medicinal materials, large loss of effective components, complicated operation and the like

Active Publication Date: 2009-03-11
SHANXI BUCHANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although such a preparation method can fully extract the active ingredients of the medicinal material in theory, there are practical problems such as complex operation, long heating time of the medicinal material, large loss of active ingredients, long production cycle, and high production cost.

Method used

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  • Traditional Chinese medicine composition with antibiotic and anti-inflammation action and preparation method and quality control method thereof
  • Traditional Chinese medicine composition with antibiotic and anti-inflammation action and preparation method and quality control method thereof
  • Traditional Chinese medicine composition with antibiotic and anti-inflammation action and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Take 800g of Houttuynia cordata and cut into 2-3cm sections, mix with 200g of honeysuckle, add 8 times the amount of pH 2.0 acid water to soak for 1 hour, extract volatile oil by steam distillation for 2 hours, collect 800ml of the first distillate, and distill the first distillate Then carry out redistillation, collect 100ml of heavy distilled liquid, separate the volatile oil for later use; filter the medicinal liquid after extracting the volatile oil, put it aside, add 6 times the amount of water to decoct the dregs of the medicine for 0.5 hours, filter, combine the two filtrates, and concentrate at 60°C To a relative density of 1.06, add ethanol to make the alcohol content to 60%, let it stand for 12 hours, and filter; recover the ethanol from the filtrate until it has no alcohol smell, dry it under reduced pressure, and grind it into 100 mesh powder; The ratio is volatile oil: β-cyclodextrin = 1:6, the inclusion temperature is 40°C, and the inclusion time is 90 minu...

Embodiment 2

[0091] Cut 800g of Houttuynia cordata into 2-3cm sections, mix with 200g of honeysuckle, add 12 times the amount of pH 5.0 acid water, soak for 4 hours, extract volatile oil by steam distillation for 6 hours, collect 1200ml of initial distillate, and distill the first distillate Then carry out redistillation, collect 400ml of heavy distilled liquid, separate the volatile oil for later use; filter the medicinal liquid after extracting the volatile oil, put it aside, add 10 times the amount of water to decoct the medicinal residue for 2 hours, filter, combine the filtrate twice, and concentrate at 60°C To a relative density of 1.10, add ethanol to make the alcohol content to 90%, let it stand for 48 hours, and filter; recover the ethanol from the filtrate until it has no alcohol smell, dry it under reduced pressure, and crush it into 100 mesh powder; For volatile oil: β-cyclodextrin = 1:6, inclusion temperature 40°C, inclusion time 90min to make β-cyclodextrin inclusion compound,...

Embodiment 3

[0093] Cut 800g of Houttuynia cordata into 2-3cm sections, mix with 200g of honeysuckle, soak in 10 times the amount of pH4.0 acidic water for 3 hours, extract the volatile oil by steam distillation for 4 hours, collect 1000ml of the first distillate, and distill the first distillate Then carry out redistillation, collect 200ml of heavy distilled liquid, separate the volatile oil for later use; filter the medicinal liquid after extracting the volatile oil, put it aside, add 8 times the amount of water to decoct the dregs of the medicine for 1 hour, filter, combine the filtrates twice, and concentrate at 60°C To a relative density of 1.06-1.10, add ethanol to make the alcohol content to 75%, let it stand for 24 hours, and filter; recover the ethanol from the filtrate until it has no alcohol smell, dry it under reduced pressure, and grind it into 100 mesh powder; use saturated aqueous solution method for volatile oil, pack The mixing ratio is volatile oil: β-cyclodextrin = 1:6, t...

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Abstract

The invention relates to a traditional Chinese medicinal composite with the antibacterial and antiphlogistic effects, a preparation method and a quality control method thereof. The composite is prepared from 800g of herba houttuyniae and 200g of flos lonicerae; wherein, pharmaceutical forms of the composite comprise oral preparations such as pills, granules, hard capsules, soft capsules, tablets, dropping pills, oral liquid preparations and the composite is characterized by definite therapeutic effect, better improvement of clinical symptoms, reasonable pharmaceutical forms, little side effect and low price; the quality control method of the oral liquid includes the identification of volatile constituents and herba houttuyniae, the examination of relative density and pH value and assay of the flos lonicerae and herba houttuyniae.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and quality control method, in particular to a traditional Chinese medicine composition with antibacterial and anti-inflammatory effects and its preparation method and quality control method. Background technique [0002] Houttuynia cordata and honeysuckle are representative traditional Chinese medicines for clearing heat and detoxifying commonly used in clinical practice. Houttuynia cordata is pungent in taste and cool in nature. Sweet and cold, its qi is delicate and fragrant, it can clear the evil heat and fire poison of the qi and blood components, and it can also unblock the expression, reduce swelling and ulcers, and relieve the poison of carbuncles. Control febrile disease, exogenous pathogenic wind-heat, the key medicine of sore carbuncle. [0003] Of the fish gold preparations, only injections are used clinically. Houttuynia cordata and honeysuckle ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61K9/16A61K9/20A61K9/48G01N30/02A61P31/04A61K47/10A61K47/26A61K47/36
Inventor 赵涛
Owner SHANXI BUCHANG PHARMA CO LTD
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