Potentilla discolor extract for reversing multidrug resistance of tumor, preparation method and application of potentilla discolor extract
A multi-drug resistance and extract technology, which is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., to achieve the effect of reversing tumor multi-drug resistance, low drug cost, and simple production methods
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Embodiment 1
[0022] 1 kg of Herba Vermilion, crushed, passed through a 40-mesh sieve, soaked with 2 times 90% ethanol for 1 day, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 80% ethanol to dissolve it, and placed it at room temperature for 1 day. Wash and filter with 80% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.04g / cm 3 The filtrate concentrate was obtained, the filtrate concentrate was spray-dried, the air inlet temperature was controlled at 110° C., the outlet air temperature was 70° C., the atomizer rotating speed was 45 rpm, and the feed rate was 3ml / min. The multidrug-resistant tumor extract is pulverized and passed through a 150-mesh sieve to obtain a fine powder of the anti-tumor multidrug-resistant extract of Herba Verbacula; after the fine powder is mixed with conventional excipients, it is pressed into tablets to obtain Tablets of herbal extracts for reversing tumor multidrug r...
Embodiment 2
[0024] 1 kg of Herba Vermilion, crushed, passed through a 40-mesh sieve, soaked in 3 times 75% ethanol for 2 days, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 70% ethanol to dissolve it, and placed it at room temperature for 2 days. Wash and filter with 70% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.03g / cm 3 The filtrate concentrate was obtained, the filtrate concentrate was spray-dried, the air inlet temperature was controlled to be 120° C., the outlet air temperature was 80° C., the atomizer rotating speed was 50 rpm, and the feed rate was 5ml / min. For the multi-drug resistant tumor extract, crush the extract and pass through a 100-mesh sieve to obtain the fine powder of the anti-tumor multi-drug resistant extract of Herba Verbacula; after the fine powder is mixed with conventional excipients, it is made into granules and packed into capsules , to obtain capsules containing...
Embodiment 3
[0026] 1 kg of Herba Verbacula, crushed, passed through a 40-mesh sieve, soaked in 5 times 55% ethanol for 3 days, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 60% ethanol to dissolve it, and placed it at room temperature for 3 days. Wash and filter with 60% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.02g / cm 3 , to obtain the filtrate concentrate, the filtrate concentrate is spray-dried, the air inlet temperature is controlled to be 130°C, the outlet air temperature is 90°C, the atomizer rotating speed is 55 rev / min, and the feed rate is 6ml / min, to obtain P. The anti-tumor multidrug-resistant extract is pulverized and passed through a 200-mesh sieve to obtain the fine powder of the anti-tumor multidrug-resistant extract of Herba Verbaculae; after the fine powder is mixed with conventional auxiliary materials, it is prepared into granules to obtain Granules containing the extra...
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