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Potentilla discolor extract for reversing multidrug resistance of tumor, preparation method and application of potentilla discolor extract

A multi-drug resistance and extract technology, which is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., to achieve the effect of reversing tumor multi-drug resistance, low drug cost, and simple production methods

Inactive Publication Date: 2013-02-06
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Descolor Cinquefoil Herb, sweet, bitter, flat, has heat-clearing and detoxifying effects; the medicinal material contains fumaric acid, gallic acid, protocatechuic acid, quercetin ( Quercetin), naringenin (naringenin), kaempferol (kaempferol), isophthalic acid (m-phthalic acid) and other chemical components, there are no reports of their ability to reverse tumor multidrug resistance

Method used

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  • Potentilla discolor extract for reversing multidrug resistance of tumor, preparation method and application of potentilla discolor extract
  • Potentilla discolor extract for reversing multidrug resistance of tumor, preparation method and application of potentilla discolor extract

Examples

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Embodiment 1

[0022] 1 kg of Herba Vermilion, crushed, passed through a 40-mesh sieve, soaked with 2 times 90% ethanol for 1 day, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 80% ethanol to dissolve it, and placed it at room temperature for 1 day. Wash and filter with 80% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.04g / cm 3 The filtrate concentrate was obtained, the filtrate concentrate was spray-dried, the air inlet temperature was controlled at 110° C., the outlet air temperature was 70° C., the atomizer rotating speed was 45 rpm, and the feed rate was 3ml / min. The multidrug-resistant tumor extract is pulverized and passed through a 150-mesh sieve to obtain a fine powder of the anti-tumor multidrug-resistant extract of Herba Verbacula; after the fine powder is mixed with conventional excipients, it is pressed into tablets to obtain Tablets of herbal extracts for reversing tumor multidrug r...

Embodiment 2

[0024] 1 kg of Herba Vermilion, crushed, passed through a 40-mesh sieve, soaked in 3 times 75% ethanol for 2 days, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 70% ethanol to dissolve it, and placed it at room temperature for 2 days. Wash and filter with 70% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.03g / cm 3 The filtrate concentrate was obtained, the filtrate concentrate was spray-dried, the air inlet temperature was controlled to be 120° C., the outlet air temperature was 80° C., the atomizer rotating speed was 50 rpm, and the feed rate was 5ml / min. For the multi-drug resistant tumor extract, crush the extract and pass through a 100-mesh sieve to obtain the fine powder of the anti-tumor multi-drug resistant extract of Herba Verbacula; after the fine powder is mixed with conventional excipients, it is made into granules and packed into capsules , to obtain capsules containing...

Embodiment 3

[0026] 1 kg of Herba Verbacula, crushed, passed through a 40-mesh sieve, soaked in 5 times 55% ethanol for 3 days, filtered, collected the filtrate, recovered the ethanol and concentrated it to a viscous liquid, added 60% ethanol to dissolve it, and placed it at room temperature for 3 days. Wash and filter with 60% ethanol, collect the filtrate, and concentrate the filtrate to a relative density of 1.02g / cm 3 , to obtain the filtrate concentrate, the filtrate concentrate is spray-dried, the air inlet temperature is controlled to be 130°C, the outlet air temperature is 90°C, the atomizer rotating speed is 55 rev / min, and the feed rate is 6ml / min, to obtain P. The anti-tumor multidrug-resistant extract is pulverized and passed through a 200-mesh sieve to obtain the fine powder of the anti-tumor multidrug-resistant extract of Herba Verbaculae; after the fine powder is mixed with conventional auxiliary materials, it is prepared into granules to obtain Granules containing the extra...

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Abstract

The invention provides a preparation method of potentilla discolor extract for reversing multidrug resistance of tumor. The preparation method includes the following steps of smashing potentilla discolor, screening by a 40-mesh screen, soaking by 2-5 times of 55-90% of ethanol for 1-3 days, filtering, collecting filtrate, recovering ethanol to concentrate to thick liquid, adding 60-80% of ethanol to dissolve the thick liquid, standing at the room temperature for 1-3 days, washing and filtering by 60-80% of ethanol, collecting filtrate, concentrating the filtrate to be concentrated filtrate with relative density of 1.02-1.04g / cm<3>, drying the concentrated filtrate to obtain the potentilla discolor extract for reversing multidrug resistance of tumor, smashing the extract, screening and obtaining fine powder of the potentilla discolor extract for reversing multidrug resistance of the tumor. The prepared potentilla discolor extract has good effect for reversing multidrug resistance of the tumor and can be applied to preparing conventional Chinese herbal preparation such as tablets, capsules and granules.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to an extract of Herba Verbacula for reversing tumor multi-drug resistance, a preparation method and application thereof. Background technique [0002] Multidrug resistance (MDR) of tumor cells to anticancer drugs is a common factor leading to the failure of tumor chemotherapy. At present, the prevalence of cancer in China is on the rise, and 90% of the deaths of cancer patients are affected by tumor drug resistance to varying degrees, so there is an urgent search for a new generation of drug resistance reversal agents that meet the above ideals. [0003] Existing research results show that a variety of mechanisms are involved in the formation of multidrug resistance in tumor cells, mainly including: cell membrane P-glycoprotein (Permeability-glycoprotein, P-gP), multidrug resistance-associated protein (Multidrug Resistance Associated Protein, MRP) Overexpre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P35/00
Inventor 蔡宇张荣华
Owner JINAN UNIVERSITY
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