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Rapidly screening and identifying method for series components in Chinese traditional medicine complex system

An identification method and a series of technologies, which are applied in material separation, material analysis, material analysis by electromagnetic means, etc., can solve the problems of time-consuming and laborious, complex traditional Chinese medicine components, and inability to achieve comprehensive identification of traditional Chinese medicine components, and achieve the effect of simplifying the cumbersome process.

Inactive Publication Date: 2009-03-11
CHINA PHARM UNIV
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AI Technical Summary

Problems solved by technology

But in general, there are still some deficiencies in the current research methods: (1) The components of traditional Chinese medicine are complex, but most of the researches cannot realize the comprehensive identification of the components of traditional Chinese medicine, but can only selectively identify the chemical components with standard reference substances
(2) The composition of traditional Chinese medicine is complex. Using various mass spectrometry techniques to analyze the components of the complex system of traditional Chinese medicine will generate massive data sets. While providing sufficient information for structure inference, it also poses new challenges to information processing technology
The method of identifying compounds one by one is time-consuming and laborious, so there is a great need for a universally applicable and rapid method for component analysis and structure identification of complex systems of traditional Chinese medicine

Method used

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  • Rapidly screening and identifying method for series components in Chinese traditional medicine complex system
  • Rapidly screening and identifying method for series components in Chinese traditional medicine complex system
  • Rapidly screening and identifying method for series components in Chinese traditional medicine complex system

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Effect test

Embodiment 1

[0045] Rapid screening and identification of a series of components in Shengmai injection.

[0046] a, preparation contains the need testing solution of each series of components in Shengmai injection

[0047] Commercially available Shengmai Injection (No.07010606, Jiangsu Suzhong Pharmaceutical Co., Ltd.) was diluted 10 times with ultrapure water, extracted with 5 times the amount of water-saturated n-butanol, and the organic layer was evaporated to dryness, dissolved in methanol and waited. analyze.

[0048] b. Use high performance liquid phase-ion trap-time-of-flight tandem mass spectrometer to scan the test solution for positive or negative ions to obtain the total ion current chromatogram, and set the ions whose abundance exceeds a certain standard during the data collection process Automatic multi-stage fragmentation.

[0049] Instrument and workstation software: high performance liquid phase-ion trap-time-of-flight tandem mass spectrometer (Shimadzu, Japan), LCMS solu...

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Abstract

The invention relates to the field of traditional Chinese medicine and pharmaceutical analysis, in particular to the component analysis in the traditional Chinese medicine complex system, and provides a universal strategy which can be used for quick screening and identification of series components in the traditional Chinese medicine complex system, the steps are as follows: test solution containing the series components in the traditional Chinese medicine complex system is prepared, the test solution is carried out positive or negative ion full scan by adopting a high-efficiency liquidoid-ion trap-flight time tandom mass spectrometer to obtain a total ion chromatogram and multi-stage fragment information, the quick screening and identification of the series components in the traditional Chinese medicine complex system are carried out by using the diagnosis ion extension strategy. The invention can be applied to the quality control of such traditional Chinese medicine preparations as traditional Chinese medicine injection and the determination of active ingredients in the traditional Chinese medicine complex system.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine and medicine analysis, in particular to component analysis of complex systems of traditional Chinese medicines. The invention can be applied to the quality control of traditional Chinese medicine preparations such as Chinese medicine injections and the determination of active ingredients in complex systems of traditional Chinese medicines. Background technique [0002] Traditional Chinese medicine is the main form of clinical application of traditional Chinese medicine and plays an important role in the cause of human health. Although many traditional Chinese medicines have been clinically used for thousands of years, and their clinical efficacy is worthy of recognition, the composition of most traditional Chinese medicines has not been elucidated so far. The main restrictive bottleneck of research on key scientific issues. The difficulty in component analysis of this complex system of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N27/64
Inventor 王广基郑超湳郝海平吴晓兰
Owner CHINA PHARM UNIV
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