A mass spectrometer using a dynamic pressure ion source

A mass spectrometer and ion source technology, applied in the field of mass spectrometers, can solve problems such as limited volume and spatial distribution, unsatisfactory, and reduced ion trap analysis performance

Inactive Publication Date: 2010-12-08
SHIMADZU RES LAB EURO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this arrangement is unsatisfactory because it limits the volume and spatial distribution of samples for analysis and, in particular, prevents the analysis of multiple samples a

Method used

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  • A mass spectrometer using a dynamic pressure ion source
  • A mass spectrometer using a dynamic pressure ion source
  • A mass spectrometer using a dynamic pressure ion source

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Embodiment Construction

[0038] refer to figure 1 , the mass spectrometer includes an ionization region 1 and a mass analysis region 2 housed in a vacuum housing 3 . It will be understood that all of the following embodiments include vacuum housings, but only in figure 1 described in. The ionization region 1 includes a first ion trap 10 for trapping ions generated by a pulsed ion source, and the mass analysis region 2 includes a second ion trap 20 for efficiently receiving and analyzing ions ejected from the first ion trap 10 . The mass analysis region 2 also includes an ion detector D for detecting ions ejected from the second ion trap 20 .

[0039] In this embodiment of the present invention, the first ion trap 10 is a quadrupole linear ion trap, and the second ion trap 20 is a hyperbolic three-dimensional ion trap including a ring electrode 21 and two end cap electrodes 22 , 23 .

[0040] The two ion traps 10, 20 are arranged in series on a common longitudinal axis X-X. The quadrupole linear io...

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Abstract

A mass spectrometer has a pulsed ion source, a first ion trap (10) for trapping ions generated by the pulsed ion source and for locating trapped ions for subsequent ejection from the first ion trap. A pulse of cooling gas is introduced into the first ion trap (10) at a peak pressure suitable for enabling the first ion trap (10) to trap ions. A turbomolecular pump (17) reduces the pressure of cooling gas before the trapped ions are ejected from the first ion trap (1) towards a second ion trap (20) for analysis. The pulsed ion source has a sample plate (14) which forms an end wall of the first ion trap (10).

Description

technical field [0001] The present invention relates to mass spectrometers; in particular, mass spectrometers having pulsed ion sources such as matrix assisted laser desorption ionization (MALDI) ion sources. Background technique [0002] The MALDI ion source has been widely used in biochemical analysis. Typically, a MALDI ion source includes a sample mixed with a radiation absorbing material to form a matrix deposited on the surface of a sample plate; this aids ionization of the sample after the matrix is ​​irradiated by laser pulses. [0003] Known instruments include a MALDI ion source combined with a time-of-flight (TOF) mass spectrometer; however, such instruments are only capable of performing simple mass spectrometry (MS) analysis. Different types of MALDI-MS interfaces have been developed over the past decade in order to combine MALDI ion sources with other, more general types of mass analyzers, or to develop hybrid systems suitable for performing cascaded mass anal...

Claims

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Application Information

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IPC IPC(8): H01J49/42H01J49/04
CPCH01J49/062H01J49/0481H01J49/164
Inventor L·丁
Owner SHIMADZU RES LAB EURO
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