Radiating color changing hydrogels three-dimensional monitor and method for making same

A three-dimensional dose and radiochromic technology, applied in the field of nuclear radiation technology and biomedical polymer materials, can solve the problem of not being able to intuitively and quickly obtain the real dose distribution of patients, and improve the sensitivity of dose response and post-irradiation stability, No pollution or toxic side effects, easy to operate effect

Inactive Publication Date: 2009-03-18
SHANGHAI UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

For example, industrial dosimeters only respond to high-dose ranges and are not suitable for radiotherapy; medical dose tablets measur...

Method used

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  • Radiating color changing hydrogels three-dimensional monitor and method for making same

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Embodiment 1

[0027] Embodiment 1: The following is an example of preparing a novel radiochromic hydrogel three-dimensional dosimeter in the present invention, and the process and steps are as follows:

[0028] 1. Take 20g of PVA-124 powder, add 180ml of ultra-pure water, heat and stir in a 90°C water bath until the PVA is completely dissolved, and make about 200ml of 10% (w / w) PVA aqueous solution, cool at room temperature for later use .

[0029] 2. Add 0.05mmol FeSO in sequence 4 ·7H 2 O, 0.0165mmol xylenol orange (XO) in a very small amount (about 5ml, negligible) of ultrapure water, completely dissolved into an orange solution, pour it into 100ml of prepared 10% (w / w) PVA In the aqueous solution, stir slowly and evenly, and add 2.5mmol H 2 SO 4 Adjust its pH value, and stand in the dark at room temperature for defoaming.

[0030] 3. The dosimeter solution prepared in step (2) is dropped into liquid nitrogen, rapidly frozen into pellets, and then stored in a refrigerator to obtain ...

Embodiment 2

[0033] Embodiment 2: The following is an example of preparing a novel radiochromic hydrogel three-dimensional dosimeter in the present invention, and the process and steps are as follows:

[0034] 1. Take 30g of PVA-124 powder, add 170ml of ultra-pure water, heat and stir in a 90°C water bath until the PVA is completely dissolved, and make about 200ml of 15% (w / w) PVA aqueous solution, cool at room temperature for later use .

[0035] 2. Add 0.05mmol FeCl in sequence 2 4H 2 O, 0.0165mmol xylenol orange (XO) in a very small amount (about 5ml, negligible) of ultrapure water, completely dissolved into an orange solution, pour it into 100ml of prepared 15% (w / w) PVA In the aqueous solution, stir slowly and evenly, and add 2.0mmol H 2 SO 4 , adjust its pH value, and stand in the dark at room temperature for defoaming.

[0036] 3. The dosimeter solution prepared in step (2) is dropped into liquid nitrogen, rapidly frozen into pellets, and then stored in a refrigerator to obtain...

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Abstract

The invention relates to a novel radiation discoloration hydrogel three-dimension dose meter and a preparation method thereof, wherein the hydrogel three-dimension dose meter is formed by mixing a polyvinyl alcohol PVA acid water solution and dose meter gel beads in a mass ratio of 20: (1-3). The invention utilizes freeze and thaw physical crosslink method to prepare the hydrogel dose meter, which has simple operation and has no pollution or toxic side effect, compared with chemical crosslink method. Under radiation, the Fe2+ of the hydrogel three-dimension dose meter is oxidized into Fe3+, and fits the xylenol orange (X0) to form a color development XO-Fe3+ complex, thereby obtaining significant color gradient change to visually observe the distribution of the radiation dose. The invention utilizes liquid nitrogen quickly freeze to prepare and disperse dose meter gel beads in a PVA substrate, thereby simulating cell independence in a certain degree, to improve the dose response sensitivity and the stability after radiation.

Description

technical field [0001] The invention relates to a novel radiochromic hydrogel three-dimensional dosimeter and a preparation method thereof, belonging to the technical fields of nuclear radiation technology and biomedical polymer materials. Background technique [0002] Radiotherapy, surgery and chemotherapy are the three most effective methods for treating tumors, and about 70% of malignant tumors require radiotherapy. Radiation therapy can effectively kill tumor cells or prevent their spread, but it may also cause damage to normal tissue cells. Clinical statistics show that when the dose deviation of the target area is within ±5% of the optimal dose, it may cause the primary tumor to go out of control or increase the radiation complications. Therefore, accurately predicting and controlling the irradiation dose of the target and its surrounding tissues is crucial to improving the curative effect and prolonging the life of tumor patients, and it is a major topic in the field...

Claims

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Application Information

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IPC IPC(8): G01T1/04C08J3/00C08L29/04C08K3/24C08K5/098C08K5/42
Inventor 陈捷曹芳琦杨黎明林汉范金辰罗文芸戎亮刘兆民
Owner SHANGHAI UNIV
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