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Solid dispersion powder of bromine sterilizing agent and preparation method and application thereof

A technology of solid dispersion and bactericide, applied in the directions of botanical equipment and methods, application, bactericide, etc., can solve problems such as restricting promotion and application, skin irritation, low solubility, etc., to improve bioavailability, The effect of accelerating the dissolution rate and improving the penetration force

Inactive Publication Date: 2009-03-25
李浩 +3
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] 3. It has an unpleasant chlorine odor and is irritating to the skin
But when this dibromohydantoin is used alone, its solubility in water is small and the dissolution rate is slow, which greatly restricts its promotion and application

Method used

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Embodiment Construction

[0023] Table 1 has listed the embodiment of the solid dispersion powder of bromine-containing sterilant of the present invention, and the data of each composition in the table is weight gram, and its preparation method is the same, all is to use grinding after the each component metering mixing of table listing It is prepared by pulverizing to a particle size of 5 μm-10 μm by using the method or jet milling method.

[0024] Table 1

[0025] Example serial number Dibromohydantoin Sulfonamide ultramicrocrystalline cellulose citric acid Povidone Anhydrous Sodium Carbonate Sodium alkylbenzene sulfonate 1 10 90 0 0 0 0 0 2 20 80 0 0 0 0 0 3 30 70 0 0 0 0 0 4 40 60 0 0 0 0 0 5 50 50 0 0 0 0 0 6 20 70 10 0 0 0 0 7 30 50 20 0 0 0 0 8 10 60 30 0 0 0 0 9 45 50 0 5 0 0 0 10 20 60 10 10 0 0 0 11 10 65 20 5 0 0 0 12 30 65 0 ...

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PUM

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Abstract

The invention provides a bromine sterilant-containing solid dispersion powder, a preparation method and the application; the sterilant is composed of 10%-50% of bromine-containing compound, 50%-90% of amine sulfonic acid, 0-30% of ultrafine crystalline cellulose, 0-10% of citric acid, 0-20% of povidone, 0-15% of anhydrous sodium carbonate and 0-15% of sodium alkylbenzene sulfonate; the components are mixed according to proportions and then ground into particles of 5um-10um through the grinding or air smashing method so as to obtain the bromine sterilant-containing solid dispersion powder. The bromine sterilant-containing solid dispersion powder improves the bioavailability of bromide and accelerates the dissolution rate of bromine-containing compounds. The bromine sterilant of the invention is prepared into the disinfection solution with a concentration of 250-400ppm, and then the disinfection solution is used to clean and disinfect the beer production equipment and pipelines in the brewhouses and can completely kill various bacteria, in line with the CRB micro-organism standard.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a solid dispersion powder of a bromine-containing sterilant and a preparation method and application thereof. Background technique [0002] For a long time, chlorine-containing sterilants have been widely used in the field of sterilants. The principle of sterilization and disinfection of chlorine-containing sterilants is based on the biocidal effect of hypochlorous acid generated after the chlorine-containing sterilizers undergo hydrolysis in water. However, during the long-term use of chlorine-containing sterilizers, the following disadvantages were found: [0003] 1. The pH range of the effective biocidal pH value of chlorine-containing sterilants is very narrow, and the lowest dissociation reaction occurs at pH 7.0. When the pH value continues to rise, hypochlorous acid is easily dissociated into hypochlorite with extremely poor biocidal power acid ions. Because hypochlorite ions have a neg...

Claims

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Application Information

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IPC IPC(8): A01N59/00A01P3/00A61L2/18A01N41/04A01N37/00
Inventor 李浩张富岭
Owner 李浩
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