Improved simulated moving bed separation method

A technology for simulating moving bed and separation methods, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve problems such as increasing system operating pressure and solvent consumption, and achieve the goal of reducing consumption and system operating pressure Effect

Active Publication Date: 2010-09-29
河北海德生物科技有限公司
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  • Abstract
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Problems solved by technology

Since zone I of the simulated moving bed requires complete regeneration of the stationary phase, it is necessary to increase the flow rate of the mobile phase in zone I when the adsorption capacity of the strongly adsorbed component is strong, which will inevitably increase the operating pressure and solvent consumption of the system

Method used

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  • Improved simulated moving bed separation method
  • Improved simulated moving bed separation method

Examples

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Effect test

Embodiment 1

[0041] Improved Simulated Moving Bed Separation Method A

[0042] use as figure 2 In the separation system shown, prepare a saturated racemic omeprazole raw material solution with a concentration of 2 mg / mL with n-hexane / absolute ethanol (volume ratio 80 / 20), and inject it at a flow rate of 17.5 mL / min. The pump P1 is directly pumped into the III area formed by the chromatographic column 5 and the chromatographic column 6, and then flows through the IV area formed by the chromatographic column 7, 8 and the IV area circulation pump P2, and normal hexane / dehydrated alcohol (volume ratio is 80 / 20) At a flow rate of 7mL / min, pump the eluent through the eluent pump P3 from the eluent inlet between the IV zone and the I zone composed of chromatographic columns 1 and 2, and then flow through the chromatographic column 3, 4 and II zone circulation pump Zone II composed of P4. The flow rates in areas I to IV were set at 23, 14.5, 17.5, and 12 mL / min, respectively. According to the...

Embodiment 2

[0045] Improved Simulated Moving Bed Separation Method B

[0046] use as image 3 In the separation system shown, prepare a saturated racemic omeprazole raw material solution with a concentration of 2 mg / mL with n-hexane / absolute ethanol (volume ratio 80 / 20), and inject it at a flow rate of 17.5 mL / min. Pump P1 directly pumps into the III area composed of chromatographic column 5 and chromatographic column 6, and then flows through the IV area composed of chromatographic column 7, 8 and IV area circulation pump P2, and flows pure absolute ethanol from The eluent inlet is directly pumped into zone I composed of chromatographic column 1 and chromatographic column 2 through eluent pump P3, and then flows through zone II composed of chromatographic column 3, 4 and zone II circulation pump P4. The flow rates in areas I to IV were set at 3.1, 2.4, 17.5, and 12 mL / min, respectively. According to the material balance of the mobile phase, the flow rates of the extract and raffinate w...

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Abstract

The invention discloses an improved simulated moving bed separation method, which comprises: separating a II zone from a III zone of a simulated moving bed, making a raw material liquid directly flow into the III zone, collecting effluents of the II zone regularly, replenishing the effluents with solvent and raw material which are then converged with the initial raw material liquid to flow into the III zone, and respectively collecting streams of weak adsorption components and strong adsorption components at a raffinate outlet and an extract outlet. When mobile phase compositions obviously influence the adsorption capacity of the strong adsorption components, a I zone is also separated from a IV zone further, effluents of the II zone and the IV zone are collected regularly and mixed, and are replenished with solvent and raw material which are then converged with the raw material liquid to flow into the III zone; wherein, the volume percentage of the solvent with strong eluting power in eluent is higher than that of the solvent with strong eluting power in the raw material liquid. The improved simulated moving bed separation method can increase the raw material treating load of thesimulated moving bed and the product concentration, meanwhile reducing the system operation pressure and solvent usage.

Description

technical field [0001] The invention relates to an improved simulated moving bed separation method. technical background [0002] In recent years, separation science is facing new challenges: the objects to be separated are becoming more and more complex, and the separation difficulty is becoming more and more difficult. At the same time, the requirements for product purity are getting higher and higher. Batch preparative chromatography, as a high-efficiency separation method, can meet these requirements to a certain extent. However, its industrial application is seriously hindered due to its inherent shortcomings such as large amount of stationary phase and mobile phase, low utilization rate of stationary phase, high dilution of separated products, and high separation cost. The simulated moving bed chromatography (Simulated Moving Bed, SMB), which was born in the 1960s, has been paid more and more attention because it overcomes the shortcomings of batch preparative chromat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/10
Inventor 危凤赵迎宪
Owner 河北海德生物科技有限公司
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