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Effervescent tablet containing imatinib mesylate and preparation method thereof

A technology of imatinib mesylate and effervescent tablets, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., to achieve fast onset of action, high drug dispersion, and easy storage and portability Effect

Inactive Publication Date: 2009-04-08
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current clinical dosage forms of imatinib mainly include tablets and capsules, which need to be swallowed by patients with water, which is inconvenient for children, the elderly and patients who cannot swallow solid drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Imatinib mesylate 50g (calculated as imatinib)

[0034] Tartaric acid 150g

[0035] Sodium bicarbonate 100g

[0036] Sucrose 170g

[0037] 5% PVP solution 5g

[0038] PEG 6000 10g

[0039] Aspartame 15g

[0040] Orange flavor 10g

[0041] Imatinib mesylate, sodium bicarbonate and 70 grams of sucrose were placed in the container and mixed for 30 minutes, and 20 mesh sieves were passed while adding 5% PVP solution, and dried at 40 degrees for 45 minutes; in addition, tartaric acid and 100 grams of sucrose were placed Mix in the container for 30 minutes, pass through a 20-mesh sieve while adding 5% PVP solution, and dry at 50 degrees for 40 minutes. The two-part granules, aspartame, orange flavor and PEG6000 were mixed for 10 minutes and compressed into 1000 tablets.

Embodiment 2

[0043] Imatinib mesylate 100g (calculated as imatinib)

[0044] Tartaric acid 130g

[0045] Sodium bicarbonate 100g

[0046] Sucrose 170g

[0047] PEG 6000 5g

[0048] Acesulfame Potassium 15g

[0049] Orange flavor 10g

[0050] Put imatinib mesylate, tartaric acid, sodium bicarbonate, sucrose, orange essence, and acesulfame potassium in a container and mix for 30 minutes, granulate on a dry granulator, add PEG6000 and mix for 10 minutes, and press into 1000 tablets .

Embodiment 3

[0052] Imatinib mesylate 100g (calculated as imatinib)

[0053] Tartaric acid 100g

[0054] Potassium Bitartrate 50g

[0055] Sodium bicarbonate 80g

[0056] Sodium carbonate 10g

[0057] Mannitol 150g

[0058] Mint essence 6g

[0059] Aspartame 10g

[0060] 5% PVP ethanol solution 50g

[0061] Put imatinib mesylate, tartaric acid, potassium hydrogen tartrate, sodium bicarbonate, sodium carbonate, mannitol, and aspartame in a container and mix for 30 minutes, while adding 5% PVP ethanol solution, while passing through a 20-mesh sieve , 40 degrees to dry for 45 minutes. Mix the dry granules and mint essence for 10 minutes, transfer to a tablet machine, and compress into 1000 tablets.

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PUM

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Abstract

The invention relates to the technical field of pharmaceutical preparation, in particular to an effervescent tablet containing imatinib mesylate and a method for preparing the same. The effervescent tablet comprises 25 to 500 milligrams of the imatinib mesylate and an acid base pair which is acceptable in pharmacy; furthermore, a filling agent, an adhesive, a disintegrating agent, a lubricating agent, a sweetening agent and a flavour modifying agent which are acceptable in pharmacy can be added in the effervescent tablet. The effervescent tablet containing the imatinib mesylate has the advantages of faster action speed compared with the tablets and capsulated drugs in the market, has convenient use and good taste in taking, and is more suitable for children, the elderly, and patients who can not swallow solid medicines.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing imatinib mesylate, more specifically, the invention relates to an effervescent imatinib mesylate tablet. The present invention also relates to a preparation method of the imatinib mesylate effervescent tablet. Background technique [0002] Imatinib Mesylate is a derivative of aniline, and is a specific tyrosine kinase inhibitor (tyrosine kinases inhibitors, TKI) developed by Swiss Novartis. On May 10, 2001, imatinib oral capsule preparation entered the US FDA’s express approval channel with a breakthrough anti-tumor mechanism, and it is used for the treatment of α-interferon-failed embryonic crisis, chronic disease and accelerated disease. Drugs for the treatment of myeloid leukemia. [0003] After extensive clinical verification, imatinib has been highly appraised by the global medical community. On February 1, 2002, the FDA approved its second indication—a drug for the treatment of ga...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K31/506A61P35/02
Inventor 潘成玉张耀春司成桃
Owner BEIJING TRADE STAR MEDICAL TECH
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