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Extracting method for active principle of traditional Chinese medicine red sage root

A technology of active ingredients and extraction methods, which is applied in the field of supercritical extraction combined with tissue crushing and extraction of active ingredients of traditional Chinese medicine Salvia miltiorrhiza, can solve the waste of raw medicinal material resources, little attention is paid to the improvement of comprehensive extraction rate, and salvianolic acid compounds cannot be extracted, etc. problems, to achieve the effect of improving utilization rate and economic benefits, ingenious and reasonable process combination, and low cost

Inactive Publication Date: 2009-04-08
阳国平 +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But due to CO 2 It is a non-polar solvent. Even if an entrainer is added, only part of the active ingredients of Danshen can be extracted. The salvianolic acid compounds of Danshen cannot be extracted basically, and remain in the medicinal material extract. The comprehensive extraction rate is only about 3.0%. Raw medicinal material resources are a great waste
However, the current research on the improvement of the extraction process of the effective components of Salvia miltiorrhiza mainly focuses on the extraction and retention of diterpene quinones, and little attention has been paid to the improvement of the comprehensive extraction rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] (1) Wash the medicinal material of Danshen and crush it into a coarse powder, and pass through a 20-mesh sieve. Weigh 300g salvia miltiorrhiza coarse powder, put into the extraction tank, adjust CO 2 The flow rate is 25L / h; CO 2 and entrainer were composed of CO 2 The pump and the entrainer pump are pumped into the pump body of each pump, and after being mixed by the fluid mixer, they flow into the collecting chamber in the extractor chamber; the extraction temperature is set at 35°C, the extraction pressure is 15MPa, and the primary separation pressure is 8MPa. The primary separation temperature is 30°C, the secondary separation pressure is 4MPa, and the secondary separation temperature is 25°C; the entrainer selects 300ml of 95% ethanol, and when the extraction pressure reaches the set parameters, it enters the extraction pool to start extraction, and the extraction time is 2 hours , discharge under reduced pressure and collect the extract, concentrate and dry to ob...

Embodiment 2

[0013] (1) Wash and crush the salvia miltiorrhiza medicinal material into coarse powder, pass through a 20-mesh sieve; weigh 2Kg salvia miltiorrhiza coarse powder, put it into the extraction pool, and adjust the CO2 flow rate to 30L / h; pump into the pump body of each pump, after being mixed by a fluid mixer, it flows into the collecting chamber in the extractor cavity; the extraction extraction temperature is set to 35°C, the extraction pressure is 15MPa, the primary stage separation pressure is 10MPa, and the primary stage separation pressure is 10MPa. The separation temperature is 30°C, the secondary separation pressure is 5MPa, and the secondary separation temperature is 35°C. The entrainer selects 2L of 95% ethanol, and when the extraction pressure reaches the set parameter, it enters the extraction pool to start extraction. The extraction time is 2 hours, and the extraction is discharged under reduced pressure and the extract is collected, concentrated and dried to obtain ...

Embodiment 3

[0015] (1) Wash the medicinal material of Danshen and crush it into a coarse powder, and pass through a 20-mesh sieve. Accurately weigh 1Kg of salvia miltiorrhiza powder, put it into the extraction pool, and adjust the CO2 flow rate to 35L / h. The CO2 and the entrainer are pumped into the pump body of each pump by the CO2 pump and the entrainer pump respectively, and after being mixed by the fluid mixer, they flow into the collecting chamber in the extractor cavity. Set the extraction temperature to 40°C, the extraction pressure to 20MPa, the primary separation pressure to 12MPa, the primary separation temperature to 30°C, the secondary separation pressure to 6MPa, and the secondary separation temperature to 40°C. Entrainer selection 95% ethanol 1L, when the extraction pressure reaches the set parameters, enter the extraction tank to start extraction, the extraction time is 1.5 hours, discharge under reduced pressure and collect the extract to concentrate and dry to obtain 12g ...

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Abstract

The invention relates to a method for extracting effective components in traditional Chinese medicine Salviae miltiorrhiza radix, which comprises the following steps: firstly, extracting a tanshinone compound by using a CO2 supercritical method, collecting the extractive liquid, and obtaining a tanshinone extractive after condensing and drying; and secondly, extracting the salvianolic acid compound in the extractive residue by using a tissue breaking method, purifying the extractive liquid by polyamide chromatography column, and collecting the eluant; and after decompressing and condensing the eluant to reclaim the solvent, and then freezing and drying the mixed solution, and finally obtaining the salvianolic acid compound. The obtained tanshinone and salvianolic acid extractives have high purity. The method has the advantages of simple processing technique, equipment investment conservation, low energy consumption, short production period, little used solvent, little environmental pollution and low cost.

Description

technical field [0001] The invention relates to a method for extracting effective components of traditional Chinese medicine, in particular to a method for extracting effective components of traditional Chinese medicine Danshen by supercritical extraction combined with tissue crushing. Background technique [0002] Salvia (radix salviae miltiorrhizae) is the dry root and rhizome of Salvia miltiorrhiza. "Pharmacopoeia of the People's Republic of China" summarizes the functions of Salvia miltiorrhiza as: "dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstrual flow, clearing heart and eliminating troubles". The chemical constituents of Danshen include fat-soluble diterpene quinones (mainly tanshinone, tanshinone II A , cryptotanshinone, etc.) and water-soluble phenolic acid compounds (mainly danshensu, protocatechualdehyde, caffeic acid, rosmarinic acid and methyl ester, salvianolic acid A, B, C, etc.) These components all play a role ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 阳国平袁洪金承怀黄志军熊兴耀刘东波
Owner 阳国平