Technique for preparing oral liquid for cough and asthma of children

A Kechuanling oral liquid and a preparation process technology, applied in the field of traditional Chinese medicine pharmacy, can solve the problems of prolonged operation time, high labor intensity, low boiling point, etc., and achieve the effects of ensuring quality and stability, reducing production costs, and reducing operating pressure

Inactive Publication Date: 2009-04-15
苏州华辰净化股份有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, in actual production, Chinese herbal medicines are bulky, consume a lot of ethanol, consume a lot, cost is high, and have a low boiling point, which is not conducive to safe production, poor safety, long cycle, high labor intensity, and poor production environment.
[0004] In addition, traditional talcum powder filter-aid plate frame filtration is generally used to filter and refine the traditional Chinese medicine liquid in the preparation process of Xiaoer Kechuanling Oral Liquid. Since this filtering method depends on the shape of the talc powder filter cake, when the amount of talc powder is not enough When it is suitable or improperly operated, the talcum powder filter cake will not be tight, which seriously affects the filtering effect of the liquid medicine, and the clarity of the liquid medicine cannot meet the requirements, so it is necessary to re-prepare the talc powder filter cake to repeatedly filter the liquid medicine, resulting in operating time Extended, the operation steps are cumbersome, and the product quality cannot be guaranteed

Method used

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  • Technique for preparing oral liquid for cough and asthma of children

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] According to the preparation technology of the children's Kechuanling oral liquid of the present embodiment, the preparation process comprises the steps:

[0019] (1) Extract the original drug liquid: put 625g of bitter almonds, 1875g of gypsum, 1250g of Radix Isatidis, 625g of Radix Glycyrrhizae, and 625g of Trichosanthes trichosanthes in an extraction pot, add water to decoct for 1 hour, and filter; then add 125g of ephedra and 125g of honeysuckle to the above drug residues Add water and decoct for 1 hour, and combine the extracts to obtain the original medicinal solution.

[0020] (2), preparation of extract: filter the original drug solution with a ceramic membrane with a membrane pore size of 200nm, control the filtration pressure at 0.4MPa, and control the temperature at 30°C to 40°C, collect the clear liquid, and concentrate the clear liquid to a relative density of about It is 1.17 (80 ℃), which is the extract.

[0021] (3), preparation of children's Kechuanlin...

Embodiment 2

[0023] According to the preparation process of the children's Kechuanling oral liquid of the present embodiment is as follows:

[0024] (1), extract the former medicinal liquid: with embodiment 1.

[0025] (2), preparation of extract: filter the original drug solution with a ceramic membrane with a membrane pore size of 100nm, control the filtration pressure at 0.3MPa, and control the temperature at 40°C to 45°C, collect the clear liquid, and concentrate the clear liquid to a relative density of about It is 1.17 (80 ℃), namely extract (about 2000ml).

[0026] (3), preparation of children's Kechuanling oral liquid: take the extract, add stevioside and sodium benzoate dissolved in hot purified water, add purified water to 10000ml, stir evenly, and use a tubular ultra- Membrane filtration, filtration pressure 0.1MPa, filtration temperature: 30-40°C, membrane flux: 200-300L / m 2 .h, to obtain the said children's Kechuanling oral liquid.

Embodiment 3

[0028] According to the preparation process of the children's Kechuanling oral liquid of the present embodiment is as follows:

[0029] (1), extract the former medicinal liquid: with embodiment 1.

[0030] (2), preparation of extract: filter the original drug solution with a ceramic membrane with a membrane pore size of 20nm, control the filtration pressure at 0.2MPa, and control the temperature at 15-20°C, collect the clear liquid, and concentrate the clear liquid to a relative density of about 1.17 (80°C), that is the extract (about 2000ml).

[0031] (3), preparation of children's Kechuanling oral liquid: take the extract, add stevioside and sodium benzoate dissolved in hot purified water, add purified water to 100000ml, stir evenly, and use a tubular ultra- Membrane filtration, filtration pressure: 0.1~0.4MPa, filtration temperature: 0℃~40℃, membrane flux: 50~300L / m 2 .h, to obtain the said children's Kechuanling oral liquid.

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Abstract

The invention relates to a preparation technique for children cough oral liquid, which comprises the following steps in turn: (1) extracting primary liquid medicine; (2) purifying the primary liquid medicine to obtain clear solution, and further condensing the clear solution to obtain extractum; and (3) preparing the liquid medicine by the extractum, flavoring and water, and then obtaining the children cough oral liquid after filtering and condensing the liquid medicine in turn, in particular, in step (2), the purifying means filtering the primary liquid medicine through an ultramicro filter film; and in step (3), the filtering is also carried out by the ultramicro filter film. Through adopting the ultramicro filter film to effectively filter the primary extracted liquid medicine, the preparation technique achieves non-alcoholization production, simplifies processes, shortens production period, and reduces energy consumption and production cost; and at the same time, through adopting a filtering technique of a tubular ultrafilter film to carry out terminal filter for the prepared liquid medicine, the preparation technique ensures the content of effective components, improves clarity of the liquid medicine, improves quality of products, and ensures quality stability of the products.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to the improvement of the preparation process of the children's Kechuanling oral liquid. Background technique [0002] Pediatric Kechuanling Oral Liquid is a traditional Chinese medicine liquid preparation refined from ephedra, gold and silver, bitter almonds, isatid root, gypsum, licorice, and Trichosanthes. For upper respiratory tract infection, tracheitis, pneumonia, cough with phlegm, and shortness of breath, it is widely welcomed by consumers. However, due to the limitations of the traditional production process, like other oral preparations of traditional Chinese medicine, it is prone to precipitation during production and storage, and it is more obvious after prolonged storage. [0003] In the fourth volume of "Ministry of Health of the People's Republic of China Drug Standards for Traditional Chinese Medicine Prescriptions", the preparation pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P11/06A61K33/06
Inventor 项振荣
Owner 苏州华辰净化股份有限公司
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