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Method of producing acrylamide

A technology of acrylamide and acrylonitrile, applied in the field of manufacturing acrylamide, can solve problems such as difficult to completely remove catalytic substances, and achieve high-quality results

Inactive Publication Date: 2009-04-15
MITSUI CHEM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, even with the method for removing impurities disclosed in the above-mentioned documents, it is difficult to completely remove substances that inhibit the catalytic action of microbial cells, etc., and there is still room for improvement from the viewpoint of effectively performing the hydration reaction of acrylonitrile.
[0008] In addition, from the viewpoint of improving the quality of acrylamide and acrylamide-based polymers, the methods disclosed in the above documents still have room for improvement.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] (Add barbituric acid during hydration reaction)

[0084] [Cultivation of bacterial cells containing nitrile hydratase]

[0085] According to the method described in Example 1 of Japanese Patent Laid-Open No. 2001-340091, No. 3 clone thallus was obtained, and similarly, the method of Example 1 was used for culturing to obtain wet thallus containing nitrile hydratase.

[0086] [production of acrylamide]

[0087]A 1 L glass flask equipped with a stirrer was prepared as the first reactor, and a 40 m Teflon (registered trademark) tube with an inner diameter of 5 mm was prepared as the second reactor. 400 g of water was previously charged in the first reactor.

[0088] The wet bacterial cells obtained by the above-mentioned culture method were suspended in pure water so as to be 12% by weight. While stirring the inside of the first reactor, the suspension was continuously fed at a rate of 11 g / h. Acrylonitrile containing 30 wtppm oxazole and 2 wtppm acrolein was continuou...

Embodiment 2

[0094] Water was added to the aqueous acrylamide solution obtained in Example 1 to prepare an aqueous acrylamide solution having a concentration of 20% by weight. 500 g of this 20% by weight aqueous solution of acrylamide was placed in a 1 L polyethylene container, and while maintaining the temperature at 18° C., dissolved oxygen in the liquid was passed through nitrogen to remove it, and immediately placed in an insulating block made of foamed styrene.

[0095] Next, separate the 200×10 -6 4,4'-azobis(4-sodium cyanovalerate) in mpm (molar ratio relative to acrylamide), 200×10 -6 mpm of dimethylaminopropionitrile and 80×10 -6 mpm of ammonium persulfate was dissolved in a small amount of water and quickly injected in that order into a 1L polyethylene container. Nitrogen gas was passed through the above-mentioned reagent in advance, and a small amount of nitrogen gas was also passed into the above-mentioned polyethylene container during injection and before and after injection...

Embodiment 3

[0100] (Add barbituric acid salt during hydration reaction)

[0101] A 0.1 M-NaOH aqueous solution was added to the barbituric acid aqueous solution to prepare a sodium barbiturate aqueous solution having a pH of 7.0.

[0102] A 1 L glass flask equipped with a stirrer was prepared as the first reactor, and a 40 m Teflon (registered trademark) tube with an inner diameter of 5 mm was prepared as the second reactor. 400 g of water was previously charged in the first reactor.

[0103] The wet bacterial cells obtained by the culture method of Example 1 were suspended in pure water so as to be 12% by weight. While stirring the inside of the first reactor, the suspension was continuously fed at a rate of 11 g / h. Acrylonitrile containing 30 wtppm oxazole and 2 wtppm acrolein was continuously added at a speed of 31g / h, and an aqueous solution of sodium barbiturate was continuously added at a speed of 38g / h. The above aqueous solution of sodium barbiturate was added to water so as to...

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Abstract

It is intended to provide a method of producing acrylamide having improved qualities at an elevated efficiency by using, for example, a microbial catalyst containing nitrile hydratase. Namely, acrylamide can be produced by subjecting acryl nitrile to a hydration reaction with the use of microbial cells or processed microbial cells containing nitrile hydratase under such conditions as allowing the presence of a compound having at least one active methylene group and / or at least a salt of this compound.

Description

technical field [0001] The present invention relates to a method for producing acrylamide, and more specifically, relates to a method for producing high-quality acrylamide by efficiently hydrating acrylonitrile using microbial cells or the like containing nitrile hydratase. Background technique [0002] As the main production method of acrylamide, a method of hydrating acrylonitrile is mentioned, for example, a method of hydrating acrylonitrile with metal copper catalysts such as Raney copper is known, or a method of using microbial cells containing nitrile hydratase and bacteria thereof is known. A method in which the body-treated product is used as a catalyst for a hydration reaction. [0003] In the above-mentioned method, compared with the method for carrying out the hydration reaction by metal copper catalyst etc. in the manufacture method of the acrylamide with the microbial cell etc. that contains nitrile hydratase as catalyzer, because the conversion rate and selecti...

Claims

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Application Information

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IPC IPC(8): C12P13/02C08F20/56
CPCC08F220/56C08F220/44C12P13/02C08F20/56
Inventor 阿部刚也福田伟志村本正则羽间宗一
Owner MITSUI CHEM INC
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