Dragon's blood extract as well as preparation method and application thereof

A technology of dragon's blood and extract, applied in the field of traditional Chinese medicine, can solve problems such as the extraction method that has not yet been seen, and achieve the effects of good nerve cell protection function and simple process route.

Active Publication Date: 2009-04-22
北京理工亘舒科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, the main functions and indications of dragon's blood are promoting blood circulation and removing blood stasis, hemostasis, analgesia, promoting muscle regeneration and reducing sores. , but there is no report on the extraction method of the total phenolic substances of dragon's blood and its use as a nerve cell protective agent

Method used

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  • Dragon's blood extract as well as preparation method and application thereof
  • Dragon's blood extract as well as preparation method and application thereof
  • Dragon's blood extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Preparation of Dragon's Blood Extract

[0052] Dracaena raw material drug (produced by Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd., approval number: Z53021662) 1Kg, add 95% (v / v) ethanol until it is completely dissolved, add distilled water until the alcohol content is 40% (v / v), filter, take the supernatant, repeat the above operation 3 times for the precipitated part, and combine the supernatants. The supernatant was passed through a macroporous adsorption resin (model YDW04) column, eluted with 40% (v / v) ethanol of 8 times the column volume, discarded the eluent, and used 80% (v / v) ethanol of 8 times the column volume Elution, the eluent recovers the solvent to dryness, and obtains 0.58Kg of dragon's blood extract, calculated in terms of dragon's blood B and 3-methoxy resveratrol, in weight percentage, wherein the content of total phenols is 52.98 %, the content of ascarin A is 0.69%, the content of ascarin B is 0.62%, the content of resveratrol i...

Embodiment 2

[0053] Example 2 Preparation of Dragon's Blood Extract

[0054] Dracaena raw material drug (produced by Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd., approval number: Z53021662) 1Kg, add 90% (v / v) ethanol until it is completely dissolved, add distilled water until the alcohol content is 40% (v / v), filter, take the supernatant, repeat the above operation 4 times for the precipitated part, and combine the supernatants. The supernatant was passed through a macroporous adsorption resin (model YDW04) column, eluted with 40% (v / v) ethanol of 10 times the column volume, discarded the eluate, and used 90% (v / v) ethanol of 10 times the column volume Elution, the eluent recovers the solvent to dryness, and obtains 0.53Kg of dragon's blood extract, which is calculated as dracaine B, and in weight percentage, wherein the content of total phenols is 55.10%, and the content of dracaena A is 0.8% %, the content of astragalus B is 0.65%, the content of resveratrol is 0.37%, the conte...

Embodiment 3

[0055] Example 3 Preparation of Dragon's Blood Extract

[0056] Dracaena raw material drug (produced by Yunnan Xishuangbanna Yulin Pharmaceutical Co., Ltd., approval number: Z53021662) 1Kg, add 95% (v / v) ethanol until it is completely dissolved, add distilled water until the alcohol content is 40% (v / v), filter, take the supernatant, repeat the above operation 5 times for the precipitated part, and combine the supernatants. The supernatant was passed through a macroporous adsorption resin (model YDW04) column, eluted with 40% (v / v) ethanol of 12 times the column volume, discarded the eluent, and used 95% (v / v) ethanol of 12 times the column volume Elution, the eluent recovers the solvent to dryness, and obtains 0.48Kg of dragon's blood extract, calculated as dracaine B, in weight percentage, wherein the content of total phenols is 62%, and the content of dracaena A is 1.2% %, the content of astragalus B is 0.86%, the content of resveratrol is 0.45%, the content of 3-methoxy ...

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Abstract

The invention discloses a dragon blood extract. Based on 3-methoxy resveratrol and loureirin B, according to weight percentage, the content of total phenol is more than 50 percent, the content of loureirin A is between 0.5 and 4.0 percent, the content of the loureirin B is between 0.4 and 2.0 percent, the content of resveratrol is between 0.1 and 2.0 percent, the content of pterostilbene is between 0.3 and 4.0 percent, and the content of the 3-methoxy resveratrol is between 0.1 and 2.5 percent. Besides, the invention also discloses a method for preparing the dragon blood extract, a method for controlling the quality, and application of a pharmaceutical composition containing the dragon blood extract. The extraction process route of the dragon blood is simple and is suitable for industrial mass production; besides, the dragon's blood extract has better nerve cell protection function, and can serve as a protective agent for nerve cells.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and more specifically, the invention relates to an extract of dragon's blood and its preparation method and application. Background technique [0002] Dracaena cochinchinensis S.C.Chen is the red resin of Dracaena cochinchinensis S.C. Chen. It is a rare and precious medicinal material shared by traditional Chinese medicine and Dai medicine. It has a medicinal history of more than 1,500 years. Dragon's blood has the functions of promoting blood circulation, removing blood stasis, hemostasis, analgesia, promoting muscle regeneration and suppressing sores. It has a good curative effect in treating cardiovascular stasis and hemorrhagic diseases, traumatic bleeding, gynecological bleeding, etc., and has distinctive characteristics of national medicine. . [0003] A large number of research results by domestic scholars have shown that the chemical composition of dragon's blood produced in C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P9/00A61P9/10A61P13/12A61P21/00A61P25/00A61P25/02A61P25/16A61P25/28A61P27/02A61P27/06G01N21/31G01N30/90
Inventor 邓玉林孟薇薇李玉娟林凡凯吕芳戴荣继金晓云陈艳辛念徐志慧
Owner 北京理工亘舒科技有限公司
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