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Chemical synthesis formula and process of veratone

A technology of chemical synthesis and veratrone, applied in chemical instruments and methods, organic chemistry, carbon-based compound preparation, etc.

Inactive Publication Date: 2012-04-18
王光辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Efforts have been made to improve the yield and purity of the product, so far there is no new process route for industrialization

Method used

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  • Chemical synthesis formula and process of veratone
  • Chemical synthesis formula and process of veratone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: mainly made up of the following components by weight:

[0029] A) 3,4-dimethoxybenzaldehyde industrial grade 98% 250kg;

[0030] B) Methyl 2-chloropropionate Industrial grade 99% 245kg;

[0031] C) Drinking water food grade 1925kg;

[0032] D) Liquid caustic soda (30%) industrial grade ion membrane 280kg;

[0033] E) hydrochloric acid (36%) industrial grade 495kg;

[0034] F) toluene industrial grade (anhydrous) 1345kg;

[0035] G) sodium carbonate industrial grade 25kg;

[0036] H) sodium chloride industrial grade 13kg;

[0037] 1) sodium methylate industrial grade 295kg.

[0038] Its specific production process is:

[0039] (1) Add 3,4-dimethoxybenzaldehyde to the mixing tank, add methyl 2-chloropropionate while stirring, raise the temperature to 60°C±2°C, stir for 45 minutes, and pump the mixture to the high level tank ;

[0040] (2) the valve at the bottom of the reactor is closed, and 745kg of toluene is added therein, and then 295kg of solid...

Embodiment 2

[0056] Embodiment 2: mainly made up of the following components by weight:

[0057] A) 3,4-dimethoxybenzaldehyde industrial grade 98% 200kg;

[0058] B) Methyl 2-chloropropionate Industrial grade 99% 230kg;

[0059] C) Drinking water food grade 1600kg;

[0060]D) Liquid caustic soda (30%) industrial grade ion membrane 250kg;

[0061] E) hydrochloric acid (36%) industrial grade 450kg;

[0062] F) toluene industrial grade (anhydrous) 700kg;

[0063] G) sodium carbonate industrial grade 20kg;

[0064] H) sodium chloride industrial grade 5kg;

[0065] 1) Sodium methylate Industrial grade 280kg.

[0066] The preparation method is the same as in Example 1.

Embodiment 3

[0067] Embodiment 3: mainly made up of the following components by weight:

[0068] A) 3,4-dimethoxybenzaldehyde industrial grade 98% 300kg;

[0069] B) Methyl 2-chloropropionate Industrial grade 99% 265kg;

[0070] C) Drinking water food grade 2000kg;

[0071] D) Liquid caustic soda (30%) industrial grade ion membrane 300kg;

[0072] E) hydrochloric acid (36%) industrial grade 520kg;

[0073] F) toluene industrial grade (anhydrous) 825kg;

[0074] G) sodium carbonate industrial grade 30kg;

[0075] H) sodium chloride industrial grade 13kg;

[0076] 1) Sodium methylate Industrial grade 320kg.

[0077] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a chemical synthesis formula and process of veratryl ketone. The technical scheme includes that the invention is mainly prepared by the following components by weight parts: A) 200-300 parts of 3, 4-dimethoxy benzaldehyde; B) 230-265 parts of 2-methyl chloropropionate; C) 1600-2000 parts of drinking water; D) 250-300 parts of liquid caustic soda (30%); E) 450-520 parts of chlorhydric acid (36%); F) 700-825 parts of toluene; G) 20-30 parts of sodium carbonate; H) 5-13 parts of sodium chloride; and I) 280-320 parts of sodium methoxide. The invention has the advantages that the formula and the process pass the industrialized test and the product yield thereof is greatly improved to achieve over 99 percent expected and product quality also represents a new stage.

Description

1. Technical field: [0001] The invention relates to a production process of veratrone, in particular to a chemical synthesis formula and process of veratrone. 2. Background technology: [0002] The chemical name of veratrone is 3,4-dimethoxypropiophenone. It is a synthetic spice, an important pharmaceutical intermediate, and the main raw material of neurodrugs with a wide range of uses. [0003] At present, there are not many manufacturers at home and abroad, and the production methods are all produced by veratraldehyde condensation hydrolysis. The method is similar, but the yield of the product and the purity of the product are very different, and the highest yield is 96%. This has resulted in an unbalanced situation where some companies are profitable and some are losing money. Now compared with veratraldehyde and veratrone, the market price difference is not very big. If the yield and purity of veratrone are not high, there will be no profit, and the profit of veratral...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C49/84C07C45/72
Inventor 王光辉
Owner 王光辉