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Unpowered micro-flow control chip for heavy metal ion on site detection and making and using method thereof

A technology of microfluidic chips and heavy metal ions, which is applied in chemical method analysis, measuring devices, biological testing, etc., can solve problems such as difficult to implement on-site detection applications, temperature changes, etc., and achieve low cost and simple operation

Active Publication Date: 2009-05-20
HANGZHOU JINCHENGYIBANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in actual use, these methods either require temperature changes or other instrument assistance, making it difficult to implement on-site detection applications

Method used

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  • Unpowered micro-flow control chip for heavy metal ion on site detection and making and using method thereof
  • Unpowered micro-flow control chip for heavy metal ion on site detection and making and using method thereof
  • Unpowered micro-flow control chip for heavy metal ion on site detection and making and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Using a silicon wafer distributed with photoetched patterns as a positive mold, using polydimethylsiloxane (PDMS) as a substrate, and using conventional methods in the field, fabricate 8 microfluidic channels (channel width 100 microns, with a depth of 20 microns) of PDMS channel sheets. After the PDMS channel sheet is peeled off from the mould, a puncher is used to punch holes at the end mark of the microchannel as a sample inlet (2mm in diameter) and a sample outlet (3mm in diameter), and its specific size is adjustable. And the glass petri dish is used as a mold, and the substrate layer is made of PDMS.

[0041] 2. Seal the PDMS channel layer and the substrate layer, put it in a glass drying dish and pump it with a vacuum pump for one hour, and immediately seal the end of the sample hole with tape after taking it out, and leave it for about 3-5 minutes. (If spare, seal and place in a sealed bag)

[0042] 3. Nanogold probes functionalized with poly-T nucleotide c...

Embodiment 2

[0060] 1. Using a silicon wafer distributed with photoetched patterns as a positive mold, using polydimethylsiloxane (PDMS) as a substrate, and using conventional methods in the field, fabricate 8 microfluidic channels (channel width 100 Micron, thickness of 3mm) PDMS channel sheet. After the PDMS channel sheet is peeled off from the mould, a puncher is used to punch holes at the end mark of the microchannel as a sample inlet (2mm in diameter) and a sample outlet (3mm in diameter), and its specific size is adjustable. And the glass petri dish is used as a mold, and the substrate layer is made of PDMS.

[0061] 2. Seal the PDMS channel layer and the substrate layer, put it in a glass drying dish and pump it with a vacuum pump for one hour, and immediately seal the end of the sample hole with tape after taking it out, and leave it for about 3-5 minutes. (If spare, seal and place in a sealed bag)

[0062] 3. Add the assembled nano-gold probes functionalized with mercaptoundecan...

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Abstract

The invention discloses a multi-channel powerless microfluidic chip for field detection of heavy metal ions and a production method and a use method thereof. The microfluidic chip comprises a substrate layer and a channel sheet layer hermetically connected with the substrate layer, wherein the channel sheet layer comprises a single or more channels, and both ends of the channels are connected with sample inlet holes and sample outlet holes respectively; the substrate layer and the channel sheet layer are both made of polydimethylsiloxane materials, and the thickness of the channel sheet layer is between 8 and 20 millimeters. A sample inlet mode of the chip does not need external energy, and can achieve the field use effect only by utilizing the ability of gas storage of polydimethylsiloxane through the vacuum-pumping pretreatment. The microfluidic chip is suitable for the real-time rapid detection of different kinds of heavy metal ions in the field when being combined with different kinds of nanometer gold probes.

Description

technical field [0001] The invention relates to the field of microfluidic chips, in particular to a microfluidic chip that does not require external energy for sampling, a method for making the chip, and a method for using it for detecting heavy metal ions. Background technique [0002] For a long time, heavy metal pollution has been widely concerned by people. The biological toxicity of mercury, lead, cadmium, chromium and other heavy metal pollution caused by industrial activities is very significant, causing great harm to human health and the environment. Taking mercury as an example, the annual emission of mercury in the world is about 15,000 tons, mainly from mercury mines, metallurgy, chlor-alkali industry, electrical industry and combustion of fossil fuels. After the inorganic mercury enters the atmospheric circulation and water circulation system, it is transformed into organic mercury (methylmercury, ethylmercury) in the living body, and the toxicity is greatly enha...

Claims

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Application Information

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IPC IPC(8): G01N31/00G01N33/48G01N35/00
Inventor 樊春海宋世平何世江
Owner HANGZHOU JINCHENGYIBANG TECH CO LTD
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