Chinese medicine granule containing spina date seed extract and preparation method thereof

A technology of extract of jujube seed and traditional Chinese medicine granules, applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, medical preparations with non-active ingredients, etc. question

Inactive Publication Date: 2012-04-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of the active ingredient of the present invention: (a): get 1380g of spinous date seed, 828g of Albizia julibrissin, 20.7g of notoginseng, 414g of licorice for subsequent use; Add licorice with 10 times the crude drug amount of water, reflux for extraction for 2 hours, filter, and the filtrate is set aside, add 10 times the crude drug amount of water to the medicinal residues, reflux and extract for 2 hours, filter, and the filtrate is set aside, add 10 times the crude drug amount of water to the medicinal residues, and reflux Extract for 2 hours, filter, combine 3 extracts, concentrate under reduced pressure below 70°C to 1g crude drug / ml (P 60 =1.06~1.09), add 95% ethanol to make alcohol content reach 60%, leave standstill overnight, filter, and filtrate reclaims ethanol to 3g crude drug / ml (P 60 =1.12~1.14), add 95% ethanol to make the alcohol content reach 80%, let stand overnight, filter, and the filtrate is concentrated under reduced pressure to a ...

Embodiment 2

[0057] The preparation of the active ingredient of the present invention: (a): get 690g of spinous date seed, 500g of Albizia julibrissin, 12.5g of notoginseng leaf saponin, 220g of licorice for subsequent use; Add licorice with 12 times the amount of crude drug water, reflux extraction for 3 hours, filter, and the filtrate is set aside, add 10 times the crude drug amount of water to the medicinal residues, reflux extraction for 2 hours, filter, and set aside the filtrate, add 8 times the crude drug amount of water to the medicinal residues, and reflux Extract for 1 hour, filter, combine the extracts for 3 times, and concentrate under reduced pressure below 70 degrees Celsius to 1g crude drug / ml (P 60 =1.06~1.09), add 95% ethanol to make alcohol content reach 60%, leave standstill overnight, filter, and filtrate reclaims ethanol to 3g crude drug / ml (P 60 =1.12~1.14), add 95% ethanol to make the alcohol content reach 80%, let stand overnight, filter, and the filtrate is concent...

Embodiment 3

[0061] The preparation of the active ingredient of the present invention: (a) take 2070g of Semen jujubee, 1200g of Albizia julibrissin, 15g of notoginseng, and 500g of licorice for later use; Extract for 5 hours, filter, and set aside the filtrate, add 12 times the crude drug amount of water to the dregs, reflux extraction for 3 hours, filter, and set aside the filtrate, add 10 times the crude drug amount of water to the dregs, reflux extraction for 2 hours, filter, and combine for 3 hours Secondary extract, below 80°C, P 60 =1.06~1.09 Concentrate under reduced pressure to 1g crude drug / ml, add 99% ethanol to make the alcohol content reach 70%, let stand overnight, filter, filtrate reclaims ethanol, in P 60 =Concentrate to 3g crude drug / ml at 1.12~1.14, add 90~99% ethanol to make the alcohol content reach 75~85%, leave it to stand overnight, filter, and the filtrate is concentrated under reduced pressure to a thick paste; (c) take Panax notoginseng leaves The saponin dry pow...

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Abstract

The invention provides a traditional Chinese medicine granular preparation containing wild jujube extractive and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g/ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing a traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing jujube seed extract and a preparation method thereof. Background technique [0002] With the rapid development of China's social economy, the acceleration of urbanization and population aging, and the influence of factors such as competitive pressure, unemployment, and changes in the pace of life, the harm of mental disorders to the health of the Chinese people is "increasingly prominent and serious." Cause insomnia, depression, neurosis, schizophrenia and other mental diseases to rise sharply. Due to the increasing incidence of the disease, it is called "the killer of the new century". People pay more and more attention to mental illness, because mental illness not only endangers the patient's own health and life, but also endangers family members and social security, causing huge econ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/40A61K36/725A61P25/20
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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