Ionization source and its application in mass spectra or ion transfer

A technology of ion mobility spectrometry and ionization source, which is applied in the field of new ionization technology, can solve the problems of high electron affinity and achieve the effect of widening the range and improving sensitivity

Active Publication Date: 2009-06-10
湖南步锐生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the negative corona ionization source is very easy to produce nitro compound ions in the air, and its electron affinity is relatively high, so it cannot react with most organic substances to ionize them, while the negative corona ionization in high-purity N 2 Although relatively stable, when any electron-withdrawing impurities (including the sample to be tested) enter the discharge area, the discharge will be quenched, so it is difficult for the corona discharge ionization source to operate in the negative ion detection mode

Method used

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  • Ionization source and its application in mass spectra or ion transfer
  • Ionization source and its application in mass spectra or ion transfer
  • Ionization source and its application in mass spectra or ion transfer

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Embodiment 1

[0036] image 3 and Figure 4 The volt-ampere characteristic curves and the discharge sustaining voltage and discharge current curves of the glow discharge under atmospheric pressure are given respectively. From image 3 It can be seen that as the voltage increases, the discharge current increases linearly; from Figure 4 It can be seen that the discharge sustaining voltage decreases exponentially with the discharge current, which is similar to the characteristics of the sub-glow discharge region of the glow discharge.

Embodiment 2

[0038] Figure 5 Given is the glow discharge at atmospheric pressure versus conventional radioactive Ni 63 Schematic diagram of the signal intensity of reagent ions changing with the electric field intensity of the ion transfer tube when the source is used as the ionization source for ion mobility spectrometry. It can be seen from the figure that with the increase of the electric field intensity of the transfer tube, the magnitude of the signal intensity increase when the glow discharge under atmospheric pressure is used as the ionization source is greater than that of the radioactive Ni 63 When the source is used as an ionization source, the signal intensity increases greatly. When the electric field strength is 360V / cm, the signal strength of the former is about twice that of the latter. If the electric field strength continues to increase, the signal strength of the former will increase more than the latter More. This will lead to the high sensitivity of the glow discharg...

Embodiment 3

[0040] Figure 6 Shown are the reagent ion signals obtained in positive ion detection mode using a glow discharge at atmospheric pressure as the ionization source. It can be seen from the figure that the obtained reagent ion peak is at 19.70 ms, corresponding to a mobility of 2.32 cm 2 V -1 the s -1 . The signal-to-noise ratio of the spectrum is good, and the signal intensity of the reagent ion is high.

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Abstract

The invention relates to an ionization source in an analytic instrument, in particular to an ionization source and application thereof in an ion mobility spectrum. The ionization source comprises a direct-current power supply, a carrier gas, a positive discharge electrode, a negative discharge electrode and a current limit resistor, wherein the current limit resistor, the positive discharge electrode and the negative discharge electrode are connected in series with a positive electrode and a negative electrode of the direct-current power supply through leads to form a series circuit; and the discharge carrier gas is introduced between the positive discharge electrode and the negative discharge electrode under normal pressure. Glow discharge is used as the ionization source under atmospheric pressure, is used for the ion mobility spectrum, can avoid use of a radioactive ionization source, improve sensitivity of the ion mobility spectrum, and widen range of the ion mobility spectrum to measure a compound.

Description

technical field [0001] The invention relates to an ionization source in an analytical instrument, specifically a new ionization technology. Using this new ionization source for ion mobility spectroscopy can avoid the use of radioactive ionization sources, improve the sensitivity of ion mobility spectroscopy, and broaden the ionization spectrum. Mobility spectroscopy measures the range of compounds. Background technique [0002] Ionization source is one of the key technologies of analytical instruments such as ion mobility spectrometry. The ionization source commonly used in traditional ion mobility spectrometry is radioactive 63 Ni ionization source. 63 Ni can emit β-rays with an average energy of 17Kev, undergo a series of complex reactions with the carrier gas, and finally form reagent ions H 3 o + (positive ion detection mode) and O 2 - (Negative ion detection mode), the reagent ions react with the sample to be tested, so that the sample to be tested is ionized. rad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/10H01J49/26G01N27/62G01N30/72G01N27/622
Inventor 李海洋董璨王卫国
Owner 湖南步锐生物科技有限公司
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