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Total saponins in Holothuria nobilis Selenka with anti-tumor function

A technology of sea cucumber total saponins and sea cucumbers, which is applied in the field of medicine, can solve the problems of few researches on the preparation methods of total saponins, and achieve the effect of remarkable drug effect, large processing capacity, and strong controllability

Inactive Publication Date: 2009-06-24
宁波保税区欣诺生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing literature is mainly on the extraction process and content determination of polysaccharides in sea cucumbers, and there are few studies on the preparation method of total saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 10 kilograms of sea cucumbers with black milk are washed, chopped, soaked successively with 95%, 85%, and 85% ethanol of 5 times the amount (weight) respectively, soaked for 7 days each time, combined ethanol leaching solution, and reclaimed ethanol under reduced pressure to obtain Liquid extract. Dissolve the liquid extract in 3 times the amount of water, filter, and pass the filtrate through a DA201-B macroporous resin column, elute with water and 50% ethanol in turn, collect the 50% ethanol eluate, recover ethanol under reduced pressure until dryness, and obtain total saponins 55 grams.

Embodiment 2

[0018] Take 20 g of total saponins of black milk sea cucumber, disperse with appropriate amount of water for injection, add appropriate amount of excipients, mix well, make granules, and dry.

[0019] The granules obtained according to the examples are divided into empty capsules according to the required dosage to obtain capsules.

[0020] The granules obtained according to the examples were directly compressed into tablets and film-coated to obtain tablets.

[0021] For the treatment of tumor diseases.

Embodiment 3

[0023] Add an appropriate amount of total saponins of black milk sea cucumber to disperse with water for injection, and spray dry or vacuum dry to obtain dry powder of black milk sea cucumber total glycosides. Take polyethylene glycol 400, add black milk sea cucumber total saponin dry powder, stir until uniform while adding, and use compression method to make soft capsules. For the treatment of tumor diseases.

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to a Holothuria nobilis Selenka saponin compound extracted from Holothuria nobilis Selenka. The invention also provides a preparation method for Holothuria nobilis Selenka saponins and application of the Holothuria nobilis Selenka saponins. The invention has the advantages that a Holothuria nobilis Selenka extract has low cost, strong controllability and stable quality.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a total saponin compound extracted from black milk sea cucumber as a raw material, including a preparation method and application of the extract. Background technique [0002] Black milk sea cucumber (Thelenota ananasJ), also known as "pineapple ginseng", is an animal of the sea cucumber class Aposticidae of the marine echinodermata. Its body is very large, generally 700mm long, 100mm wide, and 80mm high. It is widely distributed in Xisha, my country. The archipelago and the southern tip of Taiwan have the effects of nourishing liver and kidney, benefiting essence and nourishing blood. [0003] Saponin is one of the main secondary metabolites of black milk sea cucumber, which is the main material basis of its chemical defense, and has various biological activities such as antifungal, anticoagulant, immune regulation, cytotoxicity and antiviral. In the in vitro cytotoxic activity s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P35/00C07H1/08A61K35/616
Inventor 巫军张佳佳丁萍月朱可奇王忠华
Owner 宁波保税区欣诺生物技术有限公司
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