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Ceftibuten suspension

A ceftibuten and suspension technology, applied in the direction of emulsion delivery, medical preparations of non-active ingredients, organic active ingredients, etc., can solve problems such as inconvenience, and achieve high quality, good stability, and simple methods.

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the third-generation varieties need to be administered by injection, which is very inconvenient

Method used

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  • Ceftibuten suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: specification 5ml: 0.2g (1000)

[0030] prescription:

[0031] Ceftibuten 200g

[0032] Vitamin C 10g

[0033] Syrup (15%) 4600g

[0034] Carboxymethylcellulose 50g

[0035] Ethylparaben 2g

[0036] Agar 20g

[0037] Flavor 1g

[0038] Preparation method:

[0039] Swell the prescribed amount of carboxymethyl cellulose and agar in 200ml of 85°C hot water, set aside, measure the prescribed amount of vitamin C, syrup, and essence and mix evenly, add the above solution, and mix well. Add ceftibuten and stir well to disperse, then dissolve ethylparaben in 10ml ethanol and add to the mixed solution, stir, mix evenly, measure the content of intermediates, subpackage, inspect and pack the finished product.

Embodiment 2

[0040] Embodiment 2: specification 5ml: 0.2g (10000)

[0041] prescription:

[0042] Ceftibuten 2000g

[0043] Vitamin C 100g

[0044] Syrup (15%) 46000g

[0045] Carboxymethylcellulose 500g

[0046] Ethylparaben 20g

[0047] Agar 200g

[0048] Flavor 10g

[0049] Preparation method:

[0050] Swell the prescribed amount of carboxymethyl cellulose and agar in 2000ml of 85°C hot water, set aside, measure the prescribed amount of vitamin C, syrup, and essence and mix evenly, add the above solution, and mix well. Add ceftibuten and stir well to disperse, then dissolve ethylparaben in 100ml ethanol and add to the mixed solution, stir, mix evenly, measure the content of intermediates, sub-package, finished product inspection, and packaging.

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Abstract

The invention belongs to the technical field of drugs. A suspension of ceftibuten is used for treating upper respiratory tract infections, such as pharyngitis, tonsillitis, scarlatina, parasinusitis and tympanitis; lower respiratory tract infections, such as acute bronchitis, acute onset of chronic bronchitis and pneumonia; urinary tract infection; enteritis and gastro-enteritis. The suspension is characterized in that the product is an insoluble solid medicament dispersed in the liquid media, each of 5ml containing ceftibuten of 0.05-1g, preferably 0.1-0.3g. The suspension is easy to administrate by children or dysphagia patients.

Description

technical field [0001] The invention belongs to the technical field of medicines, a suspension of ceftibuten, which is used for treating upper respiratory tract infections such as pharyngitis, tonsillitis, scarlet fever, paranasal sinusitis and otitis media; lower respiratory tract infections such as acute bronchitis and acute exacerbation of chronic bronchitis , pneumonia; urinary tract infection; enteritis and gastroenteritis. Specifically, it is a preparation method of ceftibuten suspension. Background technique [0002] Cephalosporin antibiotics have the characteristics of broad antibacterial spectrum, strong antibacterial activity, high curative effect, and low toxicity, and have been widely used clinically. By 1998, 56 varieties including the first generation to the fourth generation were on the market in the world. Since the first-generation cephalosporin cephalothin was successfully developed in China in the 1970s, cephalosporin antibiotics have been greatly develop...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/107A61K31/546A61K47/38A61P31/04
Inventor 王翰斌闫艳立吴广俣
Owner BEIJING HOPE HUGE PHARM SCI
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