Compound pharmaceutical composition containing doxepin and nicotinic amide

A composition, nicotinamide technology, applied in the directions of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve the problem of no combination drug, and achieve the effect of low recurrence rate, less recurrence and good curative effect

Active Publication Date: 2009-07-01
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also no report on the combination of doxepin and nicotinamide, or the combination of two drugs to treat other diseases

Method used

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  • Compound pharmaceutical composition containing doxepin and nicotinic amide
  • Compound pharmaceutical composition containing doxepin and nicotinic amide
  • Compound pharmaceutical composition containing doxepin and nicotinic amide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Doxepin hydrochloride and niacinamide cream (1)

[0031] Doxepin Hydrochloride 50g, Niacinamide 50g, Stearic Acid 150g, Glyceryl Monostearate 45g

[0032] White Vaseline 12g, Liquid Paraffin 15g, Cetyl Alcohol 20g, Span 605g, Azone 5g

[0033] Tween 6040g, glycerin 50g ethylparaben 1g, distilled water (adjust pH to 5.5-7.5 with hydrochloric acid)

[0034] Add to 1000g

[0035] Preparation method: Dissolve doxepin hydrochloride with appropriate amount of distilled water. Melt white petrolatum, ethylparaben, cetyl alcohol, stearic acid, glyceryl monostearate, liquid paraffin, and Span on a water bath, and heat to 80°C to obtain an oil phase; , Tween, glycerin, add distilled water, and heat in a water bath to 80°C to obtain an aqueous phase. Slowly add the water phase to the oil phase and stir while adding until it condenses. Add the above-mentioned doxepin hydrochloride solution during the condensation process to obtain a cream containing nicotinamide and d...

Embodiment 2

[0036] Example 2 Doxepin hydrochloride and niacinamide cream (2)

[0037] Doxepin Hydrochloride 100g, Niacinamide 1g, Stearyl Alcohol 150g, Vaseline 150g, Tween 8030g,

[0038] Glycerin 60g, urea 45g, ethylparaben 1g, distilled water (adjust pH to 5.5-7.5 with hydrochloric acid)

[0039] Add to 1000g

[0040] Preparation method: Dissolve doxepin hydrochloride in appropriate amount of distilled water, take vaseline, ethylparaben, and stearyl alcohol, melt on a water bath, and heat to 75°C to obtain an oil phase; separately take nicotinamide, Tween 80, glycerin, and urea, Add distilled water, and heat in a water bath to 80°C to obtain an aqueous phase. Slowly add the water phase to the oil phase and stir while adding until it condenses. The doxepin hydrochloride solution is added in the condensation process to obtain a cream containing doxepin hydrochloride and nicotinamide.

Embodiment 3

[0041]Example 3 Doxepin Hydrochloride and Niacinamide Cream (3)

[0042] Doxepin hydrochloride 5g, niacinamide 100g, stearic acid 12.5g, glyceryl monostearate 17g, beeswax 5g,

[0043] 70g ozokerite, 420ml liquid paraffin, 70g white petrolatum, 10g aluminum distearate, 1g calcium hydroxide,

[0044] Ethylparaben 1g, urea 50g, distilled water (adjust the pH to 5.5-7.5 with hydrochloric acid) to 1000g

[0045] Preparation method: Dissolve doxepin hydrochloride and nicotinamide with appropriate amount of distilled water. Take stearic acid, glyceryl monostearate, beeswax, and ozokerite and heat and melt on a water bath, then add liquid paraffin, white vaseline, and aluminum distearate, and heat to 85°C. In addition, dissolve calcium hydroxide, ethylparaben, and urea in distilled water, heat to 85°C, gradually add to the oil phase, and stir while adding. Add doxepin hydrochloride and nicotinamide solution under stirring, and condense to obtain cream.

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Abstract

A compound medicament composition has doxepin and nicotinamide. 1g of medicament composition contains 5-100mg of doxepin and 1-100mg of nicotinamide. The inventive medicament composition is applied to the treatment of neurodermatitis or atopic dermatitis which has good effectiveness and uneasy recurrence.

Description

Technical field: [0001] The invention relates to a compound pharmaceutical composition containing doxepin and nicotinamide, and the application of the compound doxepin and nicotinamide in preparing medicines for treating neurodermatitis and atopic dermatitis. Background technique: [0002] Neurodermatitis and atopic dermatitis are two chronic skin diseases that are difficult to cure. Most of the existing drugs have unsatisfactory curative effects, are prone to relapse, and the side effects of drugs have brought a lot of pain to patients. [0003] Neurodermatitis, also known as chronic lichen simplex, is a chronic, common cutaneous nerve dysfunction skin disease characterized by severe itching and lichenoid lesions on the skin. Atopic dermatitis (AD), also known as atopic dermatitis and atopic dermatitis, is a chronic, recurrent, itchy, inflammatory skin disease that usually occurs in patients with a personal history or family history of allergic diseases. patients with hist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61K9/00A61K9/06A61K47/16A61K47/36A61P17/00A61K31/335
Inventor 张壹朱学琳
Owner CHONGQING HUAPONT PHARMA
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