Method for preparing 'Xinmaitong' granular formulation

Abstract

The invention relates to a preparation method of Xinmaitong granules, belonging to the pharmaceutical technique domain. The preparation method comprises: crushing notoginseng into fine powder, decocting pagodatree flower in eight-fold water for 0.5 hour after boiling out, adjusting pH to 8.5, filtering, repeating the above steps one time again, then merging the filtered liquor, cooling, adjusting pH to 4.5-5.4, static culturing, leaching precipitation, drying the filtered liquor, grinding into the dried product into fine powder. The angelica, hooked uncaria are decocted in ten-fold water for 1 hour each time and the decoction is respectively performed for two times, and the filtered liquor is merged and concentrated and ethanol is added into the concentrated product to make ethanol amount to 70%, and then the mixture is in static state and then filtered, the ethanol is recovered from the filtered liquor and the filtered liquor is concentrated to be thick paste, and the thick paste is subjected to decompression drying and crushing into fine powder to be standby. The other six raw materials such as kudzu root are extracted for two times in ten-fold water for respectively 1.5, 1 hour each time, the extracted liquor is filtered and the filtered liquor is merged and concentrated to be thick paste, the thick paste is subjected to decompression drying and crushing into fine powder. The four kinds of fine powder are uniformly mixed with a right amount of dextrin to be granulated.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Xinmaitong granules. Background technique [0002] Hypertension and hyperlipidemia often coexist. There are more than 100 million hypertensive patients in my country, and 30% to 50% of them are accompanied by hyperlipidemia. Among people over the age of 35 in my country, there are as many as 37 million patients with hypertension and hyperlipidemia. Studies have shown that the application of traditional antihypertensive drugs can reduce the incidence of stroke in hypertensive patients by 38%, but the incidence of coronary heart disease is only reduced by 16%. How to further reduce coronary heart disease events in hypertensive patients has always been an important issue in cardiovascular research. Research results have shown that, compared with placebo, hypertensive patients with normal or mildly elevated blood lipids, wh...

AI Technical Summary

Problems solved by technology

[0004] However, Xinmaitong Tablets is a common traditional Chinese medicine compound tablet with a large drug load, difficult to disintegrate, slow onset, and low bioavailability after taking it, so it cannot achieve the best drug effect.