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Medicine combination capable of improving cetirizine preparation stability

A technology of cetirizine and composition, which is applied in the field of improving the drug stability of cetirizine preparations, and can solve problems such as limitations and poor quality stability

Inactive Publication Date: 2009-07-29
海南高升医药科技开发股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of composition that can improve the stability of cetirizine preparation, solve the problem that cetirizine oral preparation is limited by auxiliary materials, quality stability is poor

Method used

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  • Medicine combination capable of improving cetirizine preparation stability
  • Medicine combination capable of improving cetirizine preparation stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Mix 5g of levocetirizine hydrochloride (L-body), 70g of microcrystalline cellulose, 40g of mannitol, 30g of cross-linked polyvinylpyrrolidone, 5g of sucralose, and 2.0g of sodium bicarbonate, and spray an appropriate amount of purified water for granulation , add 0.75g of magnesium stearate to the dry granules, and mix well to make levocetirizine hydrochloride orally disintegrating tablets.

Embodiment 2

[0015] Mix 10g of cetirizine hydrochloride (racemate), 40g of microcrystalline cellulose, 850g of pregelatinized starch, 2.2g of sodium carbonate, and 4.5g of stevioside, and spray an appropriate amount of polyvinylpyrrolidone solution for granulation to make cetirizine hydrochloride. Tirizine granules.

Embodiment 3

[0017] Mix 5g of levocetirizine hydrochloride (L-body), 60g of microcrystalline cellulose, 60g of lactose, 1.5g of sodium bicarbonate, and 1.0g of sodium carbonate evenly, spray an appropriate amount of purified water for granulation, and add 1.3g of stearic acid to the dry granules Magnesium, mixed well to make levocetirizine hydrochloride tablets.

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Abstract

The invention discloses an oral preparation composition prepared by being matched with an alkaline compound taken as a stabilizing agent in cetirizine. The stability of an oral preparation added with the stabilizing agent is greatly improved.

Description

technical field [0001] The invention provides a pharmaceutical composition capable of improving the stability of cetirizine preparations, and relates to the technical field of improving the drug stability of cetirizine preparations. Background technique [0002] Cetirizine (cetirizine) is a long-acting peripheral histamine H1 receptor antagonist. Pharmacological experiments show that it has high pharmacological activity on allergic rhinitis, asthma caused by pollen, chronic urticaria and some other physical urticaria. At the same time, the penetration of the blood-brain barrier is reduced, and the side effects on the central nervous system are reduced. [0003] As reported in the literature "Research on the Interaction of Cetirizine Hydrochloride and Excipients" (Zhang Ziran, Jiang Lingtao. Huaxi Pharmaceutical Journal. 2002, 17(5): 394-395): due to the high chemical Activity, there are a variety of excipients that cannot tolerate their chemical activity under high tempera...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61K47/04A61P37/08A61P11/06
Inventor 王小树杨贵方刘红肖文礼
Owner 海南高升医药科技开发股份有限公司
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