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Selaginella uncinata extract as well as preparation method and application thereof

An extract, the technology of Cuiyuncao, applied in the field of Cuiyuncao extract, can solve the problems of poor enrichment selectivity and complex components of phenolic components

Active Publication Date: 2009-08-12
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN101357144A discloses a method for preparing non-flavonoids and flavonoids of Cuiyuncao. The preparation is simply to divide the crude extract of Cuiyuncao into two parts. and flavonoids, and if the two parts of the extract are combined in the preparation of the drug, the composition will become very complicated, and the macroporous resin is used, and the selectivity for the enrichment of phenolic components is not strong.
[0004] The enrichment research process of phenolic components in Cuiyuncao has not been involved in the existing literature, but phenols and flavonoids are the main components of Cuiyuncao antibacterial, stasis-removing, and cough-relieving components. Extraction processing to reduce dosage when making medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Cuiyun herb 1000g, dried, crushed into coarse powder, decocted with water to extract 4 times, 1 hour each time, filtered, combined filtrate, concentrated filtrate under reduced pressure, added 95% ethanol to the concentrated solution to make the alcohol content of the liquid 45 %, stand at room temperature for 12 hours, centrifuge, take the supernatant, concentrate under reduced pressure to no alcohol, the polyamide adsorption resin that has been treated on the concentrated solution is first eluted with lower than water until the color of the eluent becomes light, Use 40% ethanol instead for elution until the phenolic acid reaction is negative, combine and collect the 40% ethanol eluted part, concentrate under reduced pressure, and dry to obtain 8.7g of Cuiyuncao extract. The total phenolic acid content in the extract is 51.7%.

Embodiment 2

[0035] Cuiyun herbal medicine 1000g, dried, crushed into coarse powder, extracted twice with 70% ethanol aqueous solution, 3 hours each time, filtered, combined filtrate, concentrated filtrate under reduced pressure, added 95% ethanol to the concentrated solution to make the alcohol content of the liquid 75%, stand at room temperature for 24 hours, filter, take the filtrate, concentrate under reduced pressure to no alcohol, and the polyamide adsorption resin that has been treated on the concentrated solution is first eluted with 15% ethanol aqueous solution until the color of the eluent becomes light , use 70% ethanol instead to elute until the phenolic acid reaction is negative, combine and collect 70% ethanol eluted parts, concentrate under reduced pressure, and dry to obtain 10.5g of Cuiyuncao extract, the total phenolic acid content in the extract was 58.9%.

Embodiment 3

[0037] Cuiyun herbal medicine is dried, crushed into coarse powder, extracted 3 times with 40% ethanol aqueous solution, 2 hours each time, filtered, combined filtrate, concentrated filtrate under reduced pressure, added 95% ethanol to the concentrated solution to make the alcohol content of the liquid 60% , stand still at room temperature for 12 hours, centrifuge, take the supernatant, concentrate under reduced pressure until there is no alcohol, and the polyamide adsorption resin that has been treated on the concentrated solution is first eluted with an aqueous ethanol solution lower than 10% until the color of the eluent is Lighten, use 60% ethanol instead to elute until the phenolic acid reaction is negative, combine and collect 60% ethanol eluted parts, concentrate under reduced pressure, and dry to obtain 8.6g of Cuiyuncao extract, the total phenols in the extract The acid content is 64.1%.

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Abstract

The invention relates to selaginella uncinata extract, a preparation method and an application thereof. The total phenolic acid content of selaginella uncinata can exceed 50% by the following steps: extracting with the polar organic solvent, alcohol-precipitating and purifying by column chromatography. The selaginella uncinata extract has the effects of relieving cough and asthma and resisting bacteria, therefore, the extract is applicable to the preparation of medicaments for relieving cough and asthma.

Description

technical field [0001] The invention relates to an extract of Cuiyuncao, the total phenolic acid content in the extract is not less than 50%, and belongs to the field of extraction and preparation of natural medicines. Background technique [0002] Selaginella uncinata (Desv.) spring, also known as blue cypress and green velvet grass, is native to the central, southern and southwestern provinces of my country. It likes humid and semi-shady environments. It often grows on damp rocks under forests and on hillsides. Or in the jungles of valleys, afraid of strong direct sunlight, it is a creeping herb with dense leaves and blue-green fluorescence, which is very beautiful. Cuiyuncao is a plant of Selaginellaceae, with slightly bitter taste and cold taste, and functions of clearing away heat and promoting dampness, detoxifying, eliminating blood stasis, and stopping bleeding. "Hunan Flora" records that it has the effect of "resolving phlegm and relieving cough". Its main componen...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P11/10A61P11/14
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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