A pill for treating cerebral apoplex and the sequela thereof

A technology for sequelae and cerebral apoplexy, applied in the field of anti-stroke dripping pills and its preparation, can solve problems such as ineffective effects, many adverse reactions of compound Chinese medicine injections, and failure to use the original prescription.

Inactive Publication Date: 2009-08-26
王英明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality standard of "Xiaoshuan Oral Liquid" promulgated by the Ministry is simple, the preparation process is simple, and the production process is unreasonable. , The dosage form should be improved. At present, some hospital preparation rooms make this pr

Method used

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  • A pill for treating cerebral apoplex and the sequela thereof
  • A pill for treating cerebral apoplex and the sequela thereof
  • A pill for treating cerebral apoplex and the sequela thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Select 120 parts by weight of Astragalus, 9 parts by weight of Angelica sinensis, 11 parts by weight of red peony root, 9 parts by weight of Chuanxiong, 9 parts by weight of peach kernel, 9 parts by weight of safflower.

[0016] Water and ethanol were used as extraction solvents. Astragaloside IV and pteroside were isolated from the medicinal material Astragalus, ligustilide was isolated from Chuanxiong, ferulic acid and benzoic acid were isolated from Angelica, and safflower yellow was isolated from safflower. The drug was extracted with water and 60% ethanol, the extract was concentrated, ethanol was added to the alcohol content of 70% for precipitation, ethanol was recovered, and the water-soluble samples were extracted with forward-extracting alcohol, and then adsorbed and separated on D101 resin column, and finally coagulated with Sephadex LH-20. Gel adsorption, elution, purification to obtain each compound, and through the determination of melting point, elemental...

Embodiment 2

[0019] Select 120 parts by weight of Astragalus, 11 parts by weight of Angelica sinensis, 12 parts by weight of red peony root, 10 parts by weight of Chuanxiong, 8 parts by weight of peach kernel, 6 parts by weight of safflower.

[0020]Water and ethanol were used as extraction solvents. Astragaloside IV and pteroside were isolated from the medicinal material Astragalus, ligustilide was isolated from Chuanxiong, ferulic acid and benzoic acid were isolated from Angelica, and safflower yellow was isolated from safflower. The drug was extracted with water and 60% ethanol, the extract was concentrated, ethanol was added to the alcohol content of 70% for precipitation, ethanol was recovered, and the water-soluble samples were extracted with forward-extracting alcohol, and then adsorbed and separated on D101 resin column, and finally coagulated with Sephadex LH-20. Gel adsorption, elution, purification to obtain each compound, and through the determination of melting point, elementa...

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Abstract

The invention discloses an anti-stroke pill for treating cerebral apoplex and the sequela thereof, which comprises the main drug ingredients based on weight parts: 80-140 of astragaloside, 6-20 of angelica, 6-30 of red paeony root, 6-20 of szechuan lovage rhizome, 6-20 of peach seed, 6-20 of safflower. The preparing method includes: extracting solvent with water and alcohol, adding concentrated alcohol to deposit protein, resin, and glycan, and then enriching flavone and glycoside of the drug liquor by a n-butylalcohol extraction method and a resin column separation method, wherein the content change is measured in each step, and finally carrying out quality standard test, stability test, and fingerprint test. The preparation of the invention is advanced, the quality is controlable and stable, the effect is defined. The pill of the invention is suitable for treating diseases of slobbering, slurred speech, limb numbness, enuresis, hemiplegia, or the like, caused by cerebral apoplex and the sequela thereof.

Description

technical field [0001] The invention relates to an anti-stroke dripping pill for treating cerebral apoplexy and its sequelae and a preparation method thereof, which are used for diseases such as drooling at the corners of the mouth, slurred speech, numbness of limbs, incontinence of enuresis, hemiplegia and the like caused by stroke and stroke sequelae, and belong to the field of medicine. technical background [0002] Stroke and its sequelae are common diseases with high morbidity, high disability rate and life-threatening diseases. Surveys in several major cities in my country show that the incidence of stroke-like cerebrovascular disease is increasing every year, and the patients tend to be younger, which poses an increasing threat to people's health. The market prospects for the treatment of stroke-related diseases are good, while the treatment of chemical drugs for stroke is mainly based on thrombolysis, which has certain side effects and high prices. Traditional Chine...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61K9/20G01N30/02G01N33/15A61P25/00A61P9/10
Inventor 王英明林小琪宋建平姜生王爱平
Owner 王英明
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