Method for improving ratio of butanol produced from clostridium

A solvent-producing Clostridium and bacterial strain technology is applied in the field of bioengineering to achieve the effect of increasing the proportion of butanol
CN101519673BInactive Publication Date: 2013-02-06SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2013-02-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for improving ratio of target product (butanol) in the fermentation products of clostridium acetobutylicum. The method inhibits the generation of acetone by effectively inhibiting the metabolic pathway from acetoacetyl-CoA to acetone in the clostridium acetobutylicum. The synthesis of acetone can be blocked by knocking out an acetoacetate decarboxylase gene so as to cause the acetoacetate decarboxylase to be inactive, thereby effectively improving the ratio of butanol in the fermentation products.
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Description

technical field

[0001] The invention belongs to the technical field of bioengineering, and in particular relates to a method for increasing the ratio of butanol produced by Clostridium. Background technique

[0002] Butanol is a bulk basic raw material with multiple uses. It can be used as a precursor for the synthesis of various organic compounds in the chemical and chemical fields such as dyes, paints, plastics, resins, and rubbers; it is necessary in the production process of antibiotics and synthetic drugs. An indispensable solvent; it is also a food-grade extractant in the food and fragrance industries. More importantly, butanol is also a high-quality fuel and fuel additive with a higher octane number than ethanol. Studies have shown that the vapor pressure and heat of vaporization of butanol are 0.63psi and 141.3kcal kg respectively -1 , 2.25psi and 204.1kcal kg lower than ethanol -1 ; Its high boiling point (118°C) and low vapor pressure help the cold start of the ...

Claims

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