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Amoxicillin dispersible tablet and production method thereof

A technology of amoxicillin and amoxicillin technical, which is applied in the field of amoxicillin dispersible tablets and its production, can solve the problems of product quality stability, complex process flow, etc., and achieve the elimination of coating process and short process flow , taste improvement effect

Active Publication Date: 2009-09-09
NORTH CHINA PHARMA COMPANY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because amoxicillin is a drug that is very sensitive to heat and humidity, and the traditional production method requires the preparation of soft materials and repeated drying of pharmaceutical raw materials, so the traditional production method not only has the problem of complicated process, but also has a negative impact on product quality. It also has a great influence on the stability of its quality

Method used

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  • Amoxicillin dispersible tablet and production method thereof
  • Amoxicillin dispersible tablet and production method thereof
  • Amoxicillin dispersible tablet and production method thereof

Examples

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Effect test

Embodiment 1

[0036] Example 1 Amoxicillin dispersible tablet of the present invention

[0037] The formula of amoxicillin dispersible tablets is as follows:

[0038] Amoxicillin Raw Powder 1500g

[0039] Microcrystalline Lactose (Cellactose-80) 400g

[0040] PVPP75g

[0041] Magnesium Stearate 15g

[0042] Cyclamate 100g

[0043] Pineapple essence (solid) 50g

[0044] The above-mentioned amoxicillin raw powder is a product produced by North China Pharmaceutical Group Xiantai Co., Ltd. in accordance with the Pharmacopoeia; the above-mentioned microcrystalline lactose (Cellactose-80) is a product produced by German Meggle Company.

[0045] According to the following method, above-mentioned raw material is made into amoxicillin dispersible tablet:

[0046] (1) Amoxicillin former drug is pulverized through a 30-mesh sieve;

[0047] (2) Mix all the above-mentioned auxiliary materials, pulverize, and pass through a 30-mesh sieve;

[0048] (3) Mix the products of the above two steps, cr...

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Abstract

The invention discloses a novel formulation of amoxicillin, and in particular relates to an amoxicillin dispersible tablet and a production method thereof. The production method adopts powder direct compression technology. The amoxicillin dispersible tablet consists of amoxicillin raw medicament and a drug carrier, wherein the drug carrier comprises a diluting agent, a disintegrant and a lubricant, and selectively comprises a sweetening agent and an aromatizer; and the weight ratio of the amoxicillin raw medicament to the drug carrier is 2:1-4:1.

Description

technical field [0001] The invention relates to a new dosage form of amoxicillin, specifically, the invention relates to a dispersible amoxicillin tablet and a production method thereof, wherein the production method adopts powder direct compression technology. Background technique [0002] Amoxicillin is a broad-spectrum antibacterial agent and one of the most widely used antibacterial drugs. [0003] Amoxicillin dispersible tablet is a better oral preparation, which has the advantages of fast absorption and high bioavailability, and is convenient to take. It can be taken directly orally, dispersed with water and swallowed, or chewed or swallowed. But most of the amoxicillin dispersible tablets on the market adopt the traditional production method, that is, at first through granulation, and then the dried granules are compressed into tablets (see attached figure 2 ), the process flow is long, and the amount of auxiliary materials used is large, which increases the producti...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/43A61K47/32A61P31/04
Inventor 王志良单金海刘书睿陈素婥路玉锋
Owner NORTH CHINA PHARMA COMPANY
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