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Pharmaceutical composition for treating diabetes and/or hyperlipemia and preparation method thereof

A composition and technology for diabetes, which are applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as the inability to completely eliminate macrovascular complications.

Active Publication Date: 2009-10-21
BEIJING UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, simply controlling blood sugar cannot completely eliminate major vascular complications such as coronary heart disease in diabetic patients.

Method used

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  • Pharmaceutical composition for treating diabetes and/or hyperlipemia and preparation method thereof
  • Pharmaceutical composition for treating diabetes and/or hyperlipemia and preparation method thereof
  • Pharmaceutical composition for treating diabetes and/or hyperlipemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0318] Embodiment 1: the preparation of capsule

[0319] Astragalus 555g Mulberry leaves 555g Pueraria 278g Alisma 555g Red yeast rice 66.6g

[0320] Take Radix Astragali, soak in 70% ethanol for 2 hours, reflux extraction twice, add 7 times of Astragalus ethanol for the first time, extract 1 hour, add 6 times of Astragalus ethanol for the second time, extract for 1 hour, filter, and combine the filtrates, Recover ethanol at a vacuum degree of ≤-0.05Mpa and a temperature of ≤70°C, and concentrate it to a thick paste with a relative density of 1.25 to 1.30 at a vacuum degree of ≤-0.06Mpa and a temperature of ≤70°C. Dry under reduced pressure at ℃ to obtain alcohol extraction dry cream A, and set aside; soak the astragalus medicinal dregs and mulberry leaves in water for 2 hours, add water to decoct twice, add astragalus medicinal residues and mulberry leaves 12 times the amount of water for the first time, and decoct for 1 Add astragalus dregs and mulberry leaves 10 times the ...

Embodiment 2

[0321] Embodiment 2: tablet

[0322] Astragalus 650g, mulberry leaves 450g, kudzu root 230g, Alisma 650g, red yeast rice 90g

[0323] Take Radix Astragali, soak in 70% ethanol for 2 hours, reflux extraction twice, add 7 times of Astragalus ethanol for the first time, extract 1 hour, add 6 times of Astragalus ethanol for the second time, extract for 1 hour, filter, and combine the filtrates, Recover ethanol at a vacuum degree of ≤-0.05Mpa and a temperature of ≤70°C, and concentrate it to a thick paste with a relative density of 1.25 to 1.30 at a vacuum degree of ≤-0.06Mpa and a temperature of ≤70°C. Dry under reduced pressure at ℃ to obtain alcohol extraction dry cream A, and set aside; soak the astragalus medicinal dregs and mulberry leaves in water for 2 hours, add water to decoct twice, add astragalus medicinal residues and mulberry leaves 12 times the amount of water for the first time, and decoct for 1 Add astragalus dregs and mulberry leaves 10 times the amount of water ...

Embodiment 3

[0324] Embodiment 3: the preparation of granule

[0325]Astragalus 450g Mulberry leaves 750g Pueraria 310g Alisma 450g Red yeast rice 30g

[0326] Take the above-mentioned five medicinal materials, add conventional auxiliary materials according to conventional methods, and make granules.

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Abstract

The invention discloses a pharmaceutical composition for treating diabetes and / or hyperlipemia and a preparation method thereof. The composition is made from five Chinese medicinal herbs: astragalus root, mulberry leaf, kudzuvine root, alisma rhizome and red rice; different components are subject to extraction, decoction, filtration, concentration and the like during a preparation process of the pharmaceutical composition to allow effective components to give full play; a large number of tests prove that the pharmaceutical composition has outstanding curative effect on the diabetes and / or hyperlipemia, safety and high safety and efficacy in clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating diabetes and / or hyperlipidemia and a preparation method thereof. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease. Its basic pathological feature is absolute or relative insufficiency of insulin secretion, or peripheral tissue insensitivity to insulin, resulting in a systemic disorder of glucose metabolism, including fat and protein metabolism disorders. disease. Many studies have confirmed that obese patients have lipid metabolism disorders long before abnormal glucose metabolism, often accompanied by varying degrees of hyperlipidemia. The main lipid metabolism abnormalities are elevated blood triglyceride (TG), decreased high-density lipoprotein-cholesterol (HDL-C) and increased low-density lipoprotein-cholesterol (LDL-C). Therefore, simply controlling blood sug...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P3/10A61P3/06
Inventor 高学敏张建军欧丽娜李伟段震文郭树仁杜保民
Owner BEIJING UNIV OF CHINESE MEDICINE
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