Fluorescence observing device and fluorescence observing method

Abstract

A lesion region in a captured fluorescent image can be made conspicuous, and an accurate diagnosis can be made. A fluorescence observing device (1) comprises a light source (2) for illuminating a region (S) to be observed with an illuminating light having a wavelength band absorbed by blood vessels and an exciting light for producing a drug fluorescence by exciting a fluorescent dye gathering singularly in a lesion, an imaging section (15, 16) for acquiring images by capturing reflected light and fluorescence produced when the region (S) is illuminated with the illuminating light and the exciting light, and an image processing section (4) for creating a reference image by smoothing the brightness of the reflected light image acquired by the imaging section (15, 16) and correcting the fluorescent image according to the acquired reference image.

Description

technical field [0001] The invention relates to a fluorescence observation device and a fluorescence observation method. Background technique [0002] Conventionally, there is known an endoscope system that irradiates an observation target site where a fluorochrome abnormally accumulated on a lesion such as a cancer cell is injected with excitation light that excites the fluorochrome to generate drug fluorescence, and By photographing the generated drug fluorescence, it is possible to obtain a fluorescence pattern with high brightness in the lesion (for example, refer to Patent Document 1). [0003] [Patent Document 1] Japanese Patent Laid-Open No. 8-224208 [0004] However, since the biological tissue to be observed originally contains autofluorescent substances, irradiating with excitation light not only excites the fluorescent pigment but also the autofluorescent substances, which has the disadvantage that the lesion is not conspicuous in the acquired fluorescence image....

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Problems solved by technology

[0004]However, since autofluorescent substances are originally contained in the biological tissue as the observation target part, by irradiating excitation light, not only the fluorescent pigment but also the autofluorescent substances are excited, which has the function of acquiring Defects that are not obvious in the lesion in the fluorescence image

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