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Matrine sustained release preparation and preparing method thereof

A technology of matrine and sustained-release tablets, which is applied in pill delivery, pharmaceutical formulations, antiviral agents, etc., can solve problems such as inconvenience, inconvenient medication, and obvious pain, and achieve high bioavailability, sufficient drug release, and blood drug Concentration stabilization effect

Inactive Publication Date: 2009-11-25
BEIJING YISCON TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The local pain is obvious when the injection is injected intramuscularly or intravenously, and it is inconvenient for patients who need long-term medication for the treatment of chronic hepatitis B or leukopenia
Kushensu Capsules need to be taken several times a day, long-term use is also inconvenient, and the blood concentration fluctuates greatly, and the "peak and valley" phenomenon is obvious, which affects the curative effect

Method used

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  • Matrine sustained release preparation and preparing method thereof
  • Matrine sustained release preparation and preparing method thereof
  • Matrine sustained release preparation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0189] Matrine 300g

[0190] Lactose 60g

[0191] 10% povidone K30 ethanol solution 60ml

[0192] Hypromellose K100M 130g

[0193] Microcrystalline Cellulose 50g

[0194] Micronized silica gel 6.0g

[0195] Magnesium stearate 3.0g made into 1000 tablets

[0196] Coating Solution Prescription:

[0197] Gastric Dissolving Film Coating Powder 10.9g

[0198] Distilled water 61.0ml

[0199] 1. Weigh matrine and lactose according to the prescription amount, mix evenly, add about 60ml of binder, stir evenly, make a suitable soft material, pass through a 18-mesh sieve to granulate;

[0200] 2. Dry the granules at 50°C, pass through a 18-mesh sieve;

[0201] 3. Determining the content of matrine in the granules and determining the tablet weight;

[0202] 4. Add the prescribed amount of hydroxypropylmethylcellulose K100M, microcrystalline cellulose, micronized silica gel, and magnesium stearate to the dry granules, and mix well;

[0203] 5. Compress the tablet with a die with ...

Embodiment 2

[0206] Matrine 300g

[0207] Lactose 50g

[0208] 10% povidone K30 ethanol solution 60ml

[0209] Hypromellose K100M 139.4g

[0210] Microcrystalline Cellulose 43.4g

[0211] Micronized silica gel 6.0g

[0212] Magnesium stearate 2.7g made into 1000 tablets

[0213] Coating Solution Prescription:

[0214] Gastric Dissolving Film Coating Powder 11.3g

[0215] Distilled water 61.0ml

[0216] 1. Weigh matrine and lactose according to the prescription amount, mix evenly, add about 60ml of binder, stir evenly, make a suitable soft material, pass through a 24-mesh sieve to granulate;

[0217] 2. Dry the granules at 60°C, pass through a 16-mesh standard sieve for granulation;

[0218] 3. Determining the content of matrine in the granules and determining the tablet weight;

[0219] 4. Add the prescribed amount of hydroxypropylmethylcellulose K100M, microcrystalline cellulose, micronized silica gel, and magnesium stearate to the dry granules, and mix well;

[0220] 5. Compres...

Embodiment 3

[0223] Matrine 300g

[0224] Lactose 59g

[0225] 10% povidone K30 ethanol solution 70ml

[0226] Hypromellose K100M 130.4g

[0227] Microcrystalline Cellulose 40g

[0228] Micronized silica gel 5.8g

[0229] Magnesium stearate 2.0g made into 1000 tablets

[0230] Coating Solution Prescription:

[0231] Gastric Dissolving Film Coating Powder 12g

[0232] Distilled water 61.0ml

[0233]1. Weigh matrine and lactose according to the prescription amount, mix evenly, add about 60ml of binder, stir evenly, make a suitable soft material, pass through a 16-mesh nylon sieve to granulate;

[0234] 2. Dry the granules at 60°C, pass through a 24-mesh standard sieve for granulation;

[0235] 3. Determining the content of matrine in the granules and determining the tablet weight;

[0236] 4. Add the prescribed amount of hydroxypropylmethylcellulose K100M, microcrystalline cellulose, micronized silica gel, and magnesium stearate to the dry granules, and mix well;

[0237] 5. Compre...

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Abstract

A matrine sustained release preparation comprises the following componets in the formula: matrine, lactose, mlcrocrystalline cellulose, 10% of polyvidone K30 ethanol solution, hydroxypropyl methyl cellulose, aerosil, magnesium stearate and stomach-dissolve type film coating powder. The matrine sustained release preparation is prepared with a method of preparing the granule with a wet method and additionally adding the mlcrocrystalline cellulose. The method of film coating is adopted so that the appearance of the sustained release tablet is more beautiful and the quality is more stable.

Description

technical field [0001] The invention relates to a matrine sustained-release preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Viral hepatitis is an infectious disease that seriously endangers people's life and health. Wide range of prevalence, high incidence rate is unmatched by other infectious diseases. The number of hepatitis B virus carriers in Asia, Africa and southern Europe is as high as 15% to 20%. China is a high-incidence area for hepatitis B virus. According to statistics, there are 1 million new hepatitis B patients every year. About 750,000 people worldwide died from liver cancer caused by chronic hepatitis B. There are more than 600 kinds of drugs for viral hepatitis in the world at present, but there is no major breakthrough so far. [0003] The main ingredient of matrine sustained-release tablets is matrine, which is an alkaloid extracted from the traditional Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/4375A61K47/38A61P1/16A61P31/14A61P31/20
Inventor 张建立曹相林蔡刚王立芹张洋
Owner BEIJING YISCON TECH
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