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Application of nicotinamide mononucleotide

A single nucleotide and nicotinamide technology, applied in the field of medicine, can solve the problems of insufficient effect, low safety, short treatment time, etc., and achieves the effect of wide treatment window, high safety, and prevention and treatment of cerebral apoplexy.

Active Publication Date: 2009-12-16
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the technical problem to be solved by the present invention is to provide a new application of nicotinamide mononucleotide and a new pharmaceutical composition

Method used

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  • Application of nicotinamide mononucleotide
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  • Application of nicotinamide mononucleotide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Nicotinamide mononucleotide reduces damage to neuron cells caused by hypoxia and glucose deficiency

[0024] Preparation of hypoxia-glucose-deficient neuron injury model, the process is as follows: the embryonic mice (Sprague-Dawley rats, Shanghai Slack Experimental Animal Co., Ltd.) were taken out, the cerebral cortex and hippocampus were separated, digested, suspended, plated again, and subjected to neuroinhibition. After the growth of glial cells, neuron cells were successfully cultured; then changed to HBSS sugar-free medium, adding 10nM FK866 [English name (E)-N-[4-(1-benzoylpiperidine-4-yl)butyl]- 3-(pyridin-3-yl) acrylamide, no Chinese name yet, compound CAS number 201034-75-5, this medicine obtains from Switzerland Apoxis company], puts into hypoxic incubator, makes oxygen content lower than 0.5% (v / v), to simulate cerebral ischemia in vitro, and at the same time administer 300 μM nicotinamide mononucleotide (purchased from Sigma-Aldrich, diluted to 3...

Embodiment 2

[0037] Example 2 Nicotinamide mononucleotide against ischemic stroke

[0038]Rats (Sprague-Dawley rats, weighing about 250 g, Shanghai Slack Experimental Animal Co., Ltd.) were used to prepare focal ischemic stroke models. hours) FK866 [English name (E)-N-[4-(1-benzoylpiperidine-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, no Chinese name yet, compound CAS number 201034-75 -5, the drug was obtained from Swiss Apoxis] After injection, the rat was anesthetized, the common carotid artery, the internal carotid artery and the external carotid artery were separated, and the nylon thread was allowed to enter the middle cerebral artery through the internal carotid artery, and after 2 hours of blocking , the thread was pulled out, and the model of focal ischemic stroke caused by middle cerebral artery blockage in rats was successfully prepared. Thirty minutes after the occlusion of the middle cerebral artery, 2 μl of nicotinamide mononucleotide with a concentration of 10 mg / ml was injected...

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Abstract

The invention discloses the application of nicotinamide mononucleotide on preparing medicines or health-care food for resisting neuronal cell injury cerebral apoplexy or oxygen-glucose deprivation. The invention also provides a novel medical composite which can effectively resist the neuronal cell injury caused by cerebral apoplexy and oxygen-glucose deprivation, thereby showing great significance to the treatment of cerebral apoplexy; and the active component in the medical composite is the nicotinamide mononucleotide which is an endogenic protective substance for an organic body and can not generate side effects according to current information, and therefore the nicotinamide mononucleotide used as a medicine has higher security and wide time window for treatment.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of nicotinamide mononucleotide in the preparation of drugs or health food for resisting cerebral stroke or neuron cell damage caused by hypoxia and glucose deficiency. Background technique [0002] The pathogenesis of ischemic stroke is complex and seriously endangers human health. Therefore, seeking the ideal drug for stroke treatment has always been one of the research hotspots in the field of cardiovascular and cerebrovascular medicine. Thrombolytics and neuroprotective agents are the main drugs used in the treatment of stroke. The deficiencies of the existing stroke treatment drugs mainly lie in the short treatment time window, insufficient safety, and unreliable effect. Moreover, most of the drugs are considered from the aspect of reducing the damage factors produced after the occurrence of cerebral infarction, and few drugs are considered from the aspect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P9/10A61P25/00A23L1/30A23L33/13
Inventor 缪朝玉王培徐添颖张偌瑜管云枫徐学文田薇薇
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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