Preparation method of nitazoxanide

Abstract

The invention relates to a preparation method of nitazoxanide. The preparation method is characterized in that 2-amido-5-nitro thiazole and anhydrous acetone are evenly mixed, a solution composed of the anhydrous acetone and o-acetyl salicylic acid chloride is added into the obtained mixed liquid, then anhydrous triethylamine is slowly dropped into the mixture when being stirred, a reaction is carried out at constant temperature, the reaction temperature is kept after the anhydrous triethylamine is dropped, the stirring is continuously carried out, the obtained reaction liquid is poured into ice water when being stirred, and the mixture stands, is filtered, is dried and is recrystallized by using ethanol to obtain the nitazoxanide. The method is simple and feasible, the yield of a final product is about 75%, the reaction step is simplified, and the production efficiency is improved.

Description

technical field

[0001] The invention relates to a preparation method of nitazoxanide for treating animal and human parasitic diseases. Background technique

[0002] In recent years, Nitazoxanide has been widely concerned as a highly effective and broad-spectrum drug against parasitic, bacterial and fungal infections in animals and humans. It is the first and only drug approved by the U.S. Drug and Food Administration (FDA). The drug for the treatment of Cryptosporidium is also the first new drug approved for the treatment of Giardia in more than 40 years. It is currently on the market in Australia, New Zealand, the United States, Canada, Mexico and other countries. The Ministry of Agriculture of my country has not yet Product registration.

[0003] Nitazoxanide is a nitrothiazole amide compound, the chemical name is 2-acetoxy-N-(5-nitro-2-thiazole)benzamide [2-(acetolyloxy)-N-(5-nitro-2 -thiazolyl)benzamide]. In the preparation of nitazoxanide, the literature method is to a...

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