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Method for producing sodium citrate

A technology of sodium citrate and citric acid, which is applied in the field of pharmaceutical adjuvant production, can solve the problems of low yield and achieve the effects of increasing yield, speeding up the reaction process, and reducing product production costs

Active Publication Date: 2014-03-12
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention therefore proposes a method for the sodium citrate of improved production, to overcome the low problem of yield in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Put 1050kg of citric acid into the reaction tank, add 1610kg of purified water, and heat until dissolved. Dissolve 530kg of sodium carbonate with 800kg of purified water in another tank, then pump it into the reaction tank in a controlled manner to react, and control the reaction temperature to be 50-60°C. After 80 minutes, add 126kg sodium hydroxide, continue reaction 60 minutes.

[0025] The reaction solution was concentrated under reduced pressure at 90°C until the concentration was d=1.45. The material was transferred into a crystallization kettle, and cold water was introduced into the jacket to grow the crystal for 3 hours, centrifuged, and dried to obtain 1210 kg of crystals (yield 82.31%).

[0026] Concentrate the crystallized mother liquor again to d=1.45, add 8% sodium chloride by weight of the secondary concentrate, fully dissolve and crystallize at 10-15°C, centrifuge and dry to obtain 205kg of crystals, according to the "Chinese Pharmacopoeia" 2005 edition...

Embodiment 2

[0028] Put 1050kg of citric acid into the reaction tank, add 1610kg of purified water, and heat until dissolved. Dissolve 636kg of sodium carbonate with 950kg of purified water in another tank, then pump it into the reaction tank in a controlled manner to react, and control the reaction temperature to be 50-60°C. After 80 minutes, add 74kg sodium hydroxide, continue reaction 60 minutes.

[0029] The reaction solution was concentrated under reduced pressure at 90°C until the concentration was d=1.45. The material was transferred into a crystallization kettle, and cold water was introduced into the jacket to grow crystals for 3 hours, centrifuged, and dried to obtain 1235 kg of crystals (yield 84.01%).

[0030] Concentrate the crystallized mother liquor again to d=1.45, add 15% sodium chloride by weight of the secondary concentrate, fully dissolve and crystallize at 10-15°C, centrifuge and dry to obtain 156kg of crystals, according to the "Chinese Pharmacopoeia" 2005 edition A...

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PUM

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Abstract

The invention provides an improved method for producing sodium citrate, comprising the following steps of: a) reacting the citric acid with sodium carbonate for 30 to 90 minutes in water solution with the temperature of 50 to 60 DEG C; b) adding sodium hydroxide in reacting mixture in the ratio of citric acid and hydroxide of 1000:3 to 12 (by weight), and reacting for a period of time; and c) concentrating the reaction liquid till d is equal to about 1.45, and crystallizing the sodium citrate; and preferably, further concentrating the mother liquor after the above crystallization till the d is equal to about 1.45, then adding little sodium chloride and carrying out secondary crystallization. The method can accelerate the reaction process, and improve the yield of the product, thus reducing the production cost of the product.

Description

technical field [0001] The invention relates to the field of pharmaceutical auxiliary production, in particular to a preparation method of sodium citrate. Background technique [0002] Sodium citrate crystal is 2-hydroxypropane-1,2,3-tricarboxylate sodium dihydrate, which is a colorless or white crystalline powder. In addition to being an anticoagulant in the pharmaceutical field, it can also be used as Buffers, injections, ophthalmic solutions, chelating agents and other excipients. [0003] The existing industrial preparation method of sodium citrate crystal is to make citric acid (also known as citric acid) react with sodium carbonate, and obtain sodium citrate dihydrate crystal by crystallization after the reaction solution is concentrated. [0004] The applicant found in production that there are such defects in the disclosed technology: 1) Since the reactants are weak acid and weak base respectively, the reaction is difficult to complete, resulting in low product yiel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C59/265C07C51/41C07C51/43
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA