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Olopatadine hydrochloride tablet as well as preparation method and detecting method thereof

A technology for olopatadine hydrochloride and prescription is applied in the field of olopatadine hydrochloride tablet and its preparation, and can solve the problems of low preparation cost, poor dissolution and high preparation cost

Active Publication Date: 2011-09-28
BEIJING SIHUAN KEBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Because the olopatadine hydrochloride tablet disclosed in the current literature has poor dissolution and high preparation cost, the present invention provides a tablet with good dissolution and low preparation cost, which has fewer auxiliary materials and can achieve a good Anti-allergic effect

Method used

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  • Olopatadine hydrochloride tablet as well as preparation method and detecting method thereof
  • Olopatadine hydrochloride tablet as well as preparation method and detecting method thereof
  • Olopatadine hydrochloride tablet as well as preparation method and detecting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Example 1: Olopatadine Hydrochloride Tablets

[0148] Olopatadine Hydrochloride 2g

[0149] Lactose 145g

[0150] Microcrystalline cellulose 30g

[0151] 2% hydroxypropyl methylcellulose 48g

[0152] Magnesium stearate 1.8g

[0153] The above raw materials are made into olopatadine hydrochloride tablets according to the conventional process.

Embodiment 2

[0154] Example 2: Olopatadine Hydrochloride Tablets

[0155] Olopatadine Hydrochloride 9g

[0156] Lactose 55g

[0157] Microcrystalline cellulose 70g

[0158] 2% hydroxypropyl methylcellulose 33g

[0159] Magnesium stearate 0.3g

[0160] The above raw materials are made into olopatadine hydrochloride tablets according to the conventional process.

Embodiment 3

[0161] Example 3: Olopatadine Hydrochloride Tablets

[0162] Olopatadine Hydrochloride 5g

[0163] 90g lactose

[0164] Microcrystalline cellulose 45g

[0165] 2% hydroxypropyl methylcellulose 40g

[0166] Magnesium stearate 1.5g

[0167] The above raw materials are made into olopatadine hydrochloride tablets according to the conventional process.

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Abstract

The invention discloses an olopatadine hydrochloride tablet as well as a preparation method and a detecting method thereof. The olopatadine hydrochloride tablet comprises the raw materials based on parts by weight: 1-10 parts of olopatadine hydrochloride, 50-150 parts of lactose, 25-75 parts of microcrystalline cellulose, 30-50 parts of 2 percent of hydroxypropyl methyl cellulose and 0.15-2.2 parts of magnesium stearate. The olopatadine hydrochloride tablet has good dissolution performance and few selected auxiliary materials and can achieve good anti-allergic effect.

Description

Technical field [0001] The invention relates to an olopatadine hydrochloride tablet and a preparation method and a detection method thereof, in particular to an olopatadine hydrochloride tablet for the treatment of allergic rhinitis, chronic urticaria or allergic conjunctivitis, and a preparation method and detection method thereof . Background technique [0002] Studies have shown that olopatadine has a better effect on allergic rhinitis, chronic urticaria, and allergic conjunctivitis. Among them, for patients with seasonal allergies, olopatadine can significantly inhibit the skin scratch reaction of histamine and grass seed pollen, and the effect is significantly stronger than terfenadine. For patients with chronic allergic rhinitis, the effectiveness and safety of olopatadine are equivalent to that of oxamide, and its therapeutic effect on nasal congestion is better than similar drugs. Patients with chronic urticaria who have taken olopatidine for a long time have a signific...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/335A61K47/38A61P11/02A61P17/00A61P27/02A61P37/08G01N21/31G01N30/02G01N30/36
Inventor 张建立曹相林陈婧陈红燕李海冰
Owner BEIJING SIHUAN KEBAO PHARM CO LTD
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