Use of glycosaminoglycan for restoring glycocalyx

A technology of glycosaminoglycan and glycocalyx, which is applied in the direction of medical preparations containing active ingredients, metabolic diseases, and extracellular fluid diseases, and can solve problems such as failure to recognize the cause of damage and the solution
CN101632686AInactive Publication Date: 2010-01-27MAASTRICHT UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MAASTRICHT UNIVERSITY
Publication Date
2010-01-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention is directed to the use of glycosaminoglycans for restoring glycocalyx functions or preventing glycocalyx damage. The effectiveness of glycosaminoglycans is directed in all pathologies where glycocalyx damage or this function may be etiologically cause of many pathologies such as: vascular disease, septic states, atherosclerosis syndrome, inflammation states and disease related to ischemia, peritoneal impairment, myocardial infarction, cerebrum- vascular events, alteration of enzymatic glycosylation in diabetes, kidney injury, intestinal disease as ulcerous colitis conditions, pneumoconiosis involving alteration of metabolic activity of pulmonary endothelium.
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Description

Background technique

[0001] The glycocalyx is a 0.5 micron thick gel layer that lines the inner walls of healthy blood vessels and is the first line of defense against many diseases.

[0002] Currently, the glycocalyx is a complex and poorly understood structure. Recent studies have shown that hyperglycemia can alter the structure of the glycocalyx, and parallel findings have suggested that the marked increase in permeability exhibited in hyperglycemia may be due to increased permeability of blood vessels to water rather than to proteins increase.

[0003] The question of restoring the functional integrity of the glycocalyx, or avoiding disruption of the glycocalyx, is a problem that involves more than one mechanism of endothelial permeability.

[0004] Given this, there is an urgent need to uncover etiological factors and mechanisms related to these degenerative changes, as targeting such processes would provide further avenues to avoid and ameliorate vascular destruction a...

Claims

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