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Aluminum-magnesium dimeticone chewable tablet and preparation method thereof

A technology of aluminum-magnesium simethicone oil and simethicone oil, which is applied in the direction of aluminum/calcium/magnesium active ingredients, pharmaceutical formulas, medical preparations of non-active ingredients, etc., and can solve the problem of inability to quantitatively control defoaming ability and weak defoaming ability and other problems, to achieve the effect of enhancing the defoaming ability, enhancing the defoaming ability, and ensuring uniformity

Inactive Publication Date: 2010-02-03
Yung Shin Pharm Ind (Kunshan) Co Ltd
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, aluminum-magnesium simethicone chewable tablets are composed of an aluminum-magnesium layer and a simethicone layer. However, simethicone is added to the tablet as a liquid preparation, and it is difficult to add liquid substances to the solid tablet. and the simethicone layer of the aluminum-magnesium simethicone chewable tablet in the prior art simply uses simethicone (Dimethicone), its defoaming ability is very weak, and it is impossible to quantitatively control the defoaming ability

Method used

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  • Aluminum-magnesium dimeticone chewable tablet and preparation method thereof
  • Aluminum-magnesium dimeticone chewable tablet and preparation method thereof
  • Aluminum-magnesium dimeticone chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Simethicone Layer:

[0030] prescription

[0031] Simethicone 18.90g

[0032] Micronized silica gel 4.50g

[0033] Carboxymethylcellulose 0.10g

[0034] Sucrose 55.00g

[0035] Microcrystalline Cellulose 99.625g

[0036] Lactose 62.815g

[0037] Red No. 7 Pigment 0.02g

[0038] Yellow No.5 Pigment 0.04g

[0039] Macrogol 6000 1.50g

[0040] Potato starch 2.50g

[0041] Sodium carboxymethyl starch 5.00g

[0042] Simethicone layer preparation process:

[0043] Mix simethicone, 1.10 g of micropowder silica gel, and carboxymethyl cellulose evenly, heat in a water bath at 80° C. for 6 hours, and cool to obtain activated simethicone.

[0044] Potato starch and pure water are mixed and dissolved to make a binder;

[0045] Mix lactose, red No. 7 pigment and yellow No. 5 pigment evenly to form a lactose pigment mixture;

[0046] Mix 0.34g micropowder silica gel and isopropanol evenly, add activated simethicone, and then add purified water.

[0047] M...

Embodiment 2

[0068] Preparation of Simethicone Layer:

[0069] prescription

[0070] Simethicone 14.025g

[0071] Micronized silica gel 4.375g

[0072] Carboxymethylcellulose 0.50g

[0073] Sucrose 62.50g

[0074] Microcrystalline Cellulose 100.00g

[0075] Lactose 50.00g

[0076] Carmine 0.02g

[0077] Lemon Yellow 0.04g

[0078] Polyethylene glycol 6000 4.54g

[0079] Potato starch 1.50g

[0080] Sodium carboxymethyl starch 7.50g

[0081] Simethicone layer preparation process:

[0082] Mix simethicone, 0.975g of micropowder silica gel, and carboxymethyl cellulose evenly, heat in a water bath at 60°C for 9 hours, and cool to obtain activated simethicone.

[0083] The potato starch and pure water are mixed and dissolved to make a binder;

[0084] Mix lactose, carmine, and tartrazine evenly to form a lactose-color mixture;

[0085] Mix 0.34g micropowder silica gel and isopropanol evenly, add activated simethicone, and then add purified water.

[0086] Mix lactose, microcrystal...

Embodiment 3

[0107] Preparation of Simethicone Layer:

[0108] prescription

[0109] Simethicone 15.98g

[0110] Micronized silica gel 4.42g

[0111] Carboxymethylcellulose 1.50g

[0112] Sucrose 35.00g

[0113] Microcrystalline Cellulose 120g

[0114] Lactose 53g

[0115] Red No. 7 Pigment 0.04g

[0116] Yellow No.5 Pigment 0.06g

[0117] Polyethylene glycol 6000 3.50g

[0118] Potato starch 3.50g

[0119] Low-substituted hydroxypropyl methylcellulose 10.00g

[0120] Simethicone layer preparation process:

[0121] Mix simethicone, 1.02g of micropowder silica gel, and carboxymethyl cellulose evenly, heat in a water bath at 100°C for 9 hours, and cool to obtain activated simethicone.

[0122] The potato starch and pure water are mixed and dissolved to make a binder;

[0123] Mix lactose, red No. 7 pigment and yellow No. 5 pigment evenly, a mixture of lactose pigment;

[0124] Mix 0.34g micropowder silica gel and isopropanol evenly, add activated simethicone, and then add purifi...

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PUM

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Abstract

The invention discloses an aluminum-magnesium dimeticone chewable tablet. The chewable tablet consists of 30 to 40 percent (by weight) of dimeticone layer and 60 to 70 percent (by weight) of aluminum-magnesium layer, and is characterized in that the dimeticone layer contains a substance which can increase the defoaming capability of dimeticone. The invention also discloses a method for preparing the aluminum-magnesium dimeticone chewable tablet. As the substance which can increase the defoaming capability of the dimeticone is added to the dimeticone layer, the aluminum-magnesium dimeticone chewable tablet provided by the invention not only can effectively enhance the defoaming capability of products, but also can quantitatively determine the defoaming capability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular, the invention relates to aluminum magnesium simethicone chewable tablets and a preparation method thereof. Background technique [0002] There are many kinds of diseases of the digestive system, and their symptoms and causes are very complicated. Generally speaking, the symptoms of gastrointestinal diseases are mainly hyperacidity, stomach pain, nausea, vomiting, diarrhea, etc. Among them, gastric discomfort caused by hyperacidity and abdominal distension caused by indigestion are the most common. The most common drugs for treating digestive system diseases are divided into antacids, H 2 Receptor antagonists and proton pump inhibitors. Among them, the effect of using antacid drugs to prevent stress upper gastrointestinal bleeding is better, and if they are taken separately with other drugs, the interaction is relatively small. [0003] Antacids are weakly alkaline salt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K33/08A61K47/34A61K47/04A61P1/04
Inventor 李芳全苏龙吴保祥
Owner Yung Shin Pharm Ind (Kunshan) Co Ltd
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