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Process for preparing hesperidin

A technology of hesperidin and tangerine peel, which is applied in the field of hesperidin preparation, can solve the problems of unfavorable large-scale production operation, serious pollution, low hesperidin content, etc., and achieve the effect of facilitating large-scale production operation, less pollution, and easy operation

Inactive Publication Date: 2010-02-10
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the extraction and separation method of hesperidin mainly adopts organic solvent method, etc., the content of hesperidin obtained by these extraction processes is low, the pollution is serious, and it is unfavorable for large-scale production operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 10Kg of tangerine peel coarse powder, add 3 times the amount of 10% ethanol to heat and reflux to extract once, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it is exhausted, filter while it is hot, refrigerate for 12 hours, filter, Wash the filter residue with water, dry at low temperature, add 50% alkaline ethanol (use KOH to adjust the pH value to 8) to dissolve, filter, add acid to the filtrate to neutralize, precipitate precipitate, collect precipitate, recrystallize with ethanol, wash and dry to obtain orange peel Glycoside 8.7g, detected by HPLC, the purity is 96.2%.

Embodiment 2

[0017] Take 10Kg of tangerine peel coarse powder, add 10 times the amount of 80% ethanol and heat and reflux to extract 3 times, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it is exhausted, filter while it is hot, refrigerate for 12 hours, filter, Wash the filter residue with water, dry at low temperature, add 50% alkaline ethanol (use NaOH to adjust the pH value to 11) to dissolve, filter, add acid to the filtrate to neutralize, precipitate precipitate, collect precipitate, recrystallize with ethanol, wash and dry to obtain orange peel Glycoside 11.7g, detected by HPLC, the purity is 94.7%.

Embodiment 3

[0019] Take 10Kg of tangerine peel coarse powder, add 8 times the amount of 70% ethanol, heat and reflux to extract twice, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it is exhausted, filter while it is hot, refrigerate for 12 hours, filter, Wash the filter residue with water, dry at low temperature, add 50% alkaline ethanol (use KOH to adjust the pH value to 8.5) to dissolve, filter, add acid to the filtrate to neutralize, precipitate out, collect the precipitate, recrystallize with ethanol, wash and dry to obtain orange peel Glycoside 10.8g, detected by HPLC, the purity is 97.9%.

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PUM

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Abstract

The invention relates to a process for preparing hesperidin, which has simple and convenient operation and less pollution and equipment investment. The process comprises the following steps: adding 3to 10 times of 10-80 percent of alcohol into dried orange peel coarse powder to heat, back flow and extract for one to three times for 2 hours each time; combining extracting liquid and filtering; decompressing filter liquid to recover the alcohol till completion; filtering when the filter liquid is hot, refrigerating for 12 hours and filtering; washing filter residues by water, drying at low temperature and adding 50 percent of alkaline alcohol to dissolve; filtering and adding acid into the filter liquid to neutralize; precipitating sediments and collecting the sediments; recrystallizing thealcohol, washing and drying to obtain the hesperidin. The process for preparing hesperidin has high product purity and is easy to realize industrialization amplification.

Description

technical field [0001] The invention relates to a method for preparing hesperidin, in particular to a method for extracting hesperidin from plants. Background technique [0002] Hesperidin (Hesperidin), synonym: tangeridin, hesperidin; molecular formula C 28 h 34 o 15 ; Mainly present in the peel of a variety of plants. [0003] Studies have shown that hesperidin can reduce the fragility and permeability of capillaries, and is used as an adjuvant treatment for hypertension and capillary hemorrhagic diseases. It has the effect of improving capillary resistance (enhancing the effect of vitamin C), has anti-inflammatory, anti-virus, and has the effect of preventing frostbite and inhibiting the aldehyde reductase of rat eye lens. [0004] In the prior art, the extraction and separation method of hesperidin mainly adopts organic solvent method, etc., the content of hesperidin obtained by these extraction processes is low, the pollution is serious, and it is not conducive to l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 王琳范淦彬
Owner SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
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