Extraction and refinement process of lincomycin

A lincomycin and process technology, applied in the field of extraction and refining process of lincomycin to reduce the B component content, can solve the problems of large impact on kidney function, non-concentrated desorption units, small resin capacity, etc., to reduce labor intensity and production cost, improved process or equipment, and the effect of desorption unit concentration

Inactive Publication Date: 2010-02-17
南阳普康药业有限公司 +1
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Problems solved by technology

Wherein, when extracting lincomycin with butanol, the B component content of the finished product is relatively high, which has great side effects on the clinical application of its derivatives, especially having a greater impact on renal function; when extracting with high carbon alcohol, although Reduce the content of B component to a certain extent, but the yield is unstable, and the production conditions and environmental

Method used

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Embodiment Construction

[0016] The process for extracting and refining lincomycin of the present invention is to acidify and filter the lincomycin fermentation liquid with oxalic acid with an activated carbon particle column to obtain an acidified filtrate; After dissolving in purified water, a lincomycin solution is obtained; the pH of the above-mentioned lincomycin acidified filtrate or solution is adjusted with NaOH, and then directly adsorbed to saturation with an activated carbon column, and then analyzed with n-butanol.

[0017] The lincomycin extraction and refining process of the present invention specifically comprises the following steps:

[0018] ①, the lincomycin fermented liquid is acidified with oxalic acid to adjust the pH to 2.0-3.5 and then filtered, and the filtrate is adjusted to pH between 8.5-10.0 with 8mol / L NaOH to obtain an alkalized liquid;

[0019] ②. Pump the above-mentioned alkalization solution into the column filled with activated carbon particles, control according to t...

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Abstract

The invention discloses an extraction and refinement process of lincomycin for reducing the content of a component B. In the extraction and refinement process, the pH of a water dissolution liquid ofa lincomycin crude product extracted by a a lincomycin fermented filtering liquid or a solvent or a water solution for recycling the crude product by using active carbon particle column through NaOH for adsorption, and deabsorption is adopted by using n-butyl alcohol. By adopting the new extraction and refinement process of lincomycin for reducing the content of the component B, to the invention improves the traditional technology or the apparatus, reduces the environmental pollution, is beneficial for biochemical performance of waste water, increases the absorption volume of the lincomycin, saves two procedures of regeneration of acid-alkali, greatly reduces the labor intensity and the production cost, and is beneficial for large scale industrial production.

Description

Technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to an extraction and refining process for reducing the content of component B of lincomycin. Background technique [0002] The traditional process of extracting lincomycin fermentation filtrate is to use solvent extraction. Wherein, when extracting lincomycin with butanol, the B component content of the finished product is relatively high, which has great side effects on the clinical application of its derivatives, especially having a greater impact on renal function; when extracting with high carbon alcohol, although Reduce the content of B component to a certain extent, but the yield is unstable, and the production conditions and environmental conditions are poor, and the activated sludge that treats its wastewater is poisoned and invalid; when the resin method is used for extraction, although the content of B component is reduced , but because ...

Claims

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Application Information

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IPC IPC(8): C07H15/16C07H1/06
Inventor 李静仁赵晴李彦博李红德吴彦赵培源薛刚
Owner 南阳普康药业有限公司
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