Extraction and refinement process of lincomycin

Abstract

The invention discloses an extraction and refinement process of lincomycin for reducing the content of a component B. In the extraction and refinement process, the pH of a water dissolution liquid ofa lincomycin crude product extracted by a a lincomycin fermented filtering liquid or a solvent or a water solution for recycling the crude product by using active carbon particle column through NaOH for adsorption, and deabsorption is adopted by using n-butyl alcohol. By adopting the new extraction and refinement process of lincomycin for reducing the content of the component B, to the invention improves the traditional technology or the apparatus, reduces the environmental pollution, is beneficial for biochemical performance of waste water, increases the absorption volume of the lincomycin, saves two procedures of regeneration of acid-alkali, greatly reduces the labor intensity and the production cost, and is beneficial for large scale industrial production.

Description

Technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to an extraction and refining process for reducing the content of component B of lincomycin. Background technique [0002] The traditional process of extracting lincomycin fermentation filtrate is to use solvent extraction. Wherein, when extracting lincomycin with butanol, the B component content of the finished product is relatively high, which has great side effects on the clinical application of its derivatives, especially having a greater impact on renal function; when extracting with high carbon alcohol, although Reduce the content of B component to a certain extent, but the yield is unstable, and the production conditions and environmental conditions are poor, and the activated sludge that treats its wastewater is poisoned and invalid; when the resin method is used for extraction, although the content of B component is reduced , but because ...

AI Technical Summary

Problems solved by technology

Wherein, when extracting lincomycin with butanol, the B component content of the finished product is relatively high, which has great side effects on the clinical application of its derivatives, especially having a greater impact on renal function; when extracting with high carbon alcohol, although Reduce the content of B component to a certain extent, but the yield is unstable, and the production conditions and environmental conditions are poor, and the activated sludge that treats its wastewater is poisoned and invalid; when the resin method is used for extraction, although the content of B component is reduced , but because the resin needs to be regenerated by two processes of acid and alkali, at the same time, the adsorption capacity of the resin is small, and the desorption units are not concentrated, which increases the production cost greatly