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Agent for preventing bleeding from cerebral cortical vein

A vascular hemorrhage and inhibitor technology, applied in the field of superficial cerebral vascular hemorrhage inhibitor, can solve the problems of unknown effect of flushing fluid, unreported prevention or inhibition, etc., and achieve the effect of inhibiting bleeding and inhibiting postoperative damage.

Active Publication Date: 2010-02-24
OTSUKA PHARM FAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the effect of the irrigating fluid on the hemostatic process is unknown, and no superficial cerebral vascular hemorrhage inhibitor capable of effectively preventing or inhibiting superficial cerebral vascular hemorrhage has been reported.

Method used

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  • Agent for preventing bleeding from cerebral cortical vein
  • Agent for preventing bleeding from cerebral cortical vein
  • Agent for preventing bleeding from cerebral cortical vein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] The components listed in Tables 1-6 below were dissolved in distilled water for injection to prepare bleeding inhibitors 1-6 of the present invention.

[0115] Table 1

[0116]

[0117] Table 2

[0118]

[0119] table 3

[0120]

[0121] Table 4

[0122]

[0123] table 5

[0124]

[0125] Table 6

[0126]

[0127] Note that bleeding inhibitors 1-4 and 6 of the present invention were prepared by dissolving all components listed in the respective tables in distilled water for injection to be handled as one-component bleeding inhibitors.

[0128] For bleeding inhibitor 5 of the present invention, the components shown in the above Table 5 titled upper chamber solution and lower chamber solution were weighed, mixed and dissolved in distilled water for injection to prepare 150 mL of upper chamber solution and 350 mL of lower chamber solution. chamber solution. Such as figure 1 As shown, the solution of the lower chamber thus obtained is loa...

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PUM

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Abstract

Disclosed is an agent for preventing the bleeding from a cerebral cortical vein, which comprises an aqueous solution containing 120 to 160 mEq / L of a sodium ion, 1 to 5 mEq / L of a calcium ion and 75 to 165 mEq / L of a chlorine ion. The agent may further contain 1 to 5 mEq / L of a potassium ion. Also disclosed is a packaged product of a container accommodating the agent therein. The agent can preventor reduce the bleeding from a cerebral cortical vein effectively in the field of neurosurgery including intracranial surgery, thereby providing a sufficiently spacious operation field during a surgery or preventing the occurrence of any disorder after a surgery.

Description

field of invention [0001] The present invention relates to a superficial cerebral vascular hemorrhage inhibitor having an effect of inhibiting superficial cerebral vascular hemorrhage during intracranial surgery and similar operations in the field of neurosurgery, and a package containing the container for the superficial cerebral vascular hemorrhage inhibitor . Background technique [0002] Removal of tissue during brain tumor resection surgery and similar procedures is often accompanied by bleeding. Under physiological conditions, this bleeding at the surgical site stops due to blood clotting and / or vasoconstriction. When bleeding persists, use electrocautery, oxidized cellulose, gelatin sponge, fibrin glue, etc. for hemostasis. [0003] When bleeding continues during surgery, it not only obscures the surgical field, but can further lead to inflammatory damage to brain cells. Therefore, early physiological hemostasis in massive bleeding sites is believed to be of great ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61J1/05A61K31/19A61K31/7004A61K33/10A61P7/04A61P41/00A61P43/00
CPCA61K33/00A61K31/19A61K33/14A61K33/10A61K31/7004A61P7/00A61P7/04A61P9/00A61P41/00A61P43/00A61K2300/00A61J1/05
Inventor 藤田泰毅土居和久上川秀士
Owner OTSUKA PHARM FAB INC
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