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Minocycline hydroehloride sustained- release tablets and preparation method thereof

A technology of minocycline hydrochloride and sustained-release tablets, which can be applied in the field of medicine and can solve problems such as difficulties

Inactive Publication Date: 2010-03-03
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After conventional preparations are taken, the drug concentration rises rapidly to the maximum value, and then decreases rapidly due to metabolism, excretion and degradation. It is difficult to control the drug concentration between the minimum effective concentration and the maximum safe concentration;

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] prescription

[0034] Minocycline Hydrochloride 90g

[0035] Hydroxypropyl methylcellulose (K100LV) 80g

[0036] Lactose (Flowlac100) 70g

[0037] Copovidone 20g

[0038] Micronized silica gel 1.3g

[0039] Talc powder 3g

[0040] Magnesium Stearate 3g

[0041] A total of 1000 pieces were made

[0042] Coating material

[0043] Opadry (03B61194) 7.5g

[0044] Water 42.5g

[0045] Preparation process

[0046] (1) Preparation of plain tablets

[0047] (1.1) Granule preparation Minocycline hydrochloride was passed through an 80-mesh sieve and set aside. Weigh successively the hydroxypropyl methylcellulose (K100LV), minocycline hydrochloride, lactose (Flowlac100) and copovidone of prescription quantity, mix uniformly, then add appropriate amount of magnesium stearate, dry granulate after mixing uniformly, Circulate until the particles between 16 mesh and 80 mesh are more than 80%, mix the fine powder under 80 mesh with the prescribed amount of micropowder silica...

Embodiment 2

[0051] prescription

[0052] Minocycline Hydrochloride 45g

[0053] Hydroxypropyl methylcellulose (K100LV) 80g

[0054] Lactose (Flowlac100) 70g

[0055] Copovidone 20g

[0056] Micronized silica gel 1g

[0057] Talc powder 2.5g

[0058] Magnesium Stearate 2.5g

[0059] A total of 1000 pieces were made

[0060] Coating material

[0061]Opadry (03B61194) 7.5g

[0062] Water 42.5g

[0063] Preparation process

[0064] (1) Preparation of plain tablets

[0065] (1.1) Granule preparation Minocycline hydrochloride was passed through an 80-mesh sieve and set aside. Weigh successively the hydroxypropyl methylcellulose (K100LV), minocycline hydrochloride, lactose (Flowlac100) and copovidone of prescription quantity, mix uniformly, then add appropriate amount of magnesium stearate, dry granulate after mixing uniformly, Circulate until the particles between 16 mesh and 80 mesh are more than 80%, mix the fine powder under 80 mesh with the prescribed amount of micropowder silic...

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PUM

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Abstract

The invention aims to provide minocycline hydroehloride sustained-release tablets with higher stability of medicament release and administrative safety, which are characterized by consisting of minocycline hydroehloride, a slow release material, a filler, a binder, a lubricating agent and a coating material. The minocycline hydroehloride sustained-release tablets have the characteristics of havingconvenient administration, lasting effect and stable curative effect, reducing untoward effect, improving the compliance of patients and the like.

Description

technical field [0001] The invention relates to a minocycline hydrochloride sustained-release tablet and a preparation method thereof, belonging to the field of medicine. technical background [0002] Minocycline hydrochloride is a semi-synthetic tetracycline broad-spectrum antibiotic with high efficiency and long-lasting effect. Among the tetracycline antibiotics, this product has the strongest antibacterial effect. The antibacterial spectrum is similar to that of tetracycline. It has a strong effect on Gram-positive bacteria, including tetracycline-resistant Staphylococcus aureus, Streptococcus, etc., and Neisseria gonorrhoeae in Gram-negative bacteria; the effect on Gram-negative bacilli is generally weak; this product is effective on trachoma Chlamydia and Ureaplasma urealyticum also have good inhibitory effect. In recent years, due to the abuse of tetracycline antibiotics, most of the common Gram-positive and negative bacteria are resistant to this product. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/30A61K31/65A61P31/04
Inventor 郑顺利林鹏李育巧
Owner COSCI MED TECH CO LTD
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