5-lipoxygenase inhibitor and preparation method, medical composite and application thereof

A solvate, compound technology, applied in 5-lipoxygenase inhibitor, application in medicine, compound of general formula and the field of preparation thereof, can solve the problems of low bioavailability, methemoglobin and the like
CN101684098AInactive Publication Date: 2010-03-31SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2010-03-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a 5-lipoxygenase inhibitor and a preparation method, a medical composite and an application thereof. More specifically, the invention provides a compound shown in general formula (I) or acceptable salt, solvate or hydrate thereof in pharmacy. The invention also relates to a preparation method, medical composite and application of the compound. The biological activity experiment shows that the compound of the invention is effective 5-LOX small molecule inhibitor with novel structure. Therefore the compound is expected to be developed to be new powerful chemical entity forcuring diseases related to leukotriene.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a 5-lipoxygenase inhibitor used for treating diseases related to leukotrienes. More specifically, the present invention relates to a novel compound of general formula (I) with a pyrimidine structure capable of inhibiting 5-lipoxygenase and a preparation method thereof; the present invention also relates to pharmaceutical compositions comprising such compounds, and Application of the compound and its pharmaceutical composition in preparing medicines for preventing and treating diseases related to 5-lipoxygenase metabolic pathway. Background technique

[0002] 5-Lipoxygenase (5-LOX) is a key enzyme in the process of arachidonic acid (AA) metabolism to produce biologically active leukotrienes (LTs). Leukotrienes can cause lung contraction, pulmonary mucus secretion, and increase vascular permeability. They are not only a powerful constrictor of coronary arteries, but also have th...

Claims

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